Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2044761..2045068 Replicon chromosome
Accession NZ_CP034014
Organism Staphylococcus aureus strain P1D1C1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EFD67_RS10075 Protein ID WP_011447039.1
Coordinates 2044892..2045068 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2044761..2044900 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD67_RS10035 2040106..2040366 + 261 WP_001791826.1 hypothetical protein -
EFD67_RS10040 2040419..2040769 - 351 WP_000702262.1 complement inhibitor SCIN-A -
EFD67_RS10045 2041452..2041901 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
EFD67_RS10050 2041996..2042330 - 335 Protein_1926 SH3 domain-containing protein -
EFD67_RS10055 2042977..2043468 - 492 WP_000920042.1 staphylokinase -
EFD67_RS10060 2043659..2044414 - 756 WP_002955266.1 CHAP domain-containing protein -
EFD67_RS10065 2044426..2044680 - 255 WP_000611512.1 phage holin -
EFD67_RS10070 2044732..2044839 + 108 WP_031762631.1 hypothetical protein -
- 2044761..2044900 + 140 NuclAT_0 - Antitoxin
- 2044761..2044900 + 140 NuclAT_0 - Antitoxin
- 2044761..2044900 + 140 NuclAT_0 - Antitoxin
- 2044761..2044900 + 140 NuclAT_0 - Antitoxin
EFD67_RS10075 2044892..2045068 - 177 WP_011447039.1 putative holin-like toxin Toxin
EFD67_RS10080 2045271..2046044 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
EFD67_RS10085 2046465..2046839 - 375 WP_000340977.1 hypothetical protein -
EFD67_RS10090 2046895..2047182 - 288 WP_001262621.1 hypothetical protein -
EFD67_RS10095 2047228..2047380 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2040419..2095624 55205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T114947 WP_011447039.1 NZ_CP034014:c2045068-2044892 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T114947 NZ_CP034014:c2045068-2044892 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT114947 NZ_CP034014:2044761-2044900 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References