Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2175181..2175695 | Replicon | chromosome |
| Accession | NZ_CP080566 | ||
| Organism | Staphylococcus aureus strain HL20835 isolate HL20835 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | A0A0H3K0C1 |
| Locus tag | JMO16_RS11000 | Protein ID | WP_001078344.1 |
| Coordinates | 2175181..2175507 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | JMO16_RS11005 | Protein ID | WP_223200634.1 |
| Coordinates | 2175510..2175695 (-) | Length | 62 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMO16_RS10975 (2170405) | 2170405..2170746 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| JMO16_RS10980 (2171196) | 2171196..2171837 | - | 642 | WP_063663566.1 | pathogenicity island protein | - |
| JMO16_RS10985 (2171834) | 2171834..2172214 | - | 381 | WP_000356942.1 | hypothetical protein | - |
| JMO16_RS10990 (2172524) | 2172524..2174233 | - | 1710 | WP_000447473.1 | DUF927 domain-containing protein | - |
| JMO16_RS10995 (2174247) | 2174247..2175116 | - | 870 | WP_001002689.1 | primase alpha helix C-terminal domain-containing protein | - |
| JMO16_RS11000 (2175181) | 2175181..2175507 | - | 327 | WP_001078344.1 | DUF1474 family protein | Toxin |
| JMO16_RS11005 (2175510) | 2175510..2175695 | - | 186 | WP_223200634.1 | pathogenicity island protein | Antitoxin |
| JMO16_RS11010 (2175712) | 2175712..2175858 | - | 147 | WP_000784885.1 | hypothetical protein | - |
| JMO16_RS11015 (2175855) | 2175855..2176172 | - | 318 | WP_000481967.1 | helix-turn-helix domain-containing protein | - |
| JMO16_RS11020 (2176177) | 2176177..2176395 | - | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| JMO16_RS11025 (2176568) | 2176568..2177242 | + | 675 | WP_000620857.1 | helix-turn-helix transcriptional regulator | - |
| JMO16_RS11030 (2177256) | 2177256..2178428 | + | 1173 | WP_000179343.1 | tyrosine-type recombinase/integrase | - |
| JMO16_RS11035 (2178497) | 2178497..2180113 | - | 1617 | WP_000240642.1 | chaperonin GroEL | - |
| JMO16_RS11040 (2180189) | 2180189..2180473 | - | 285 | WP_000917289.1 | co-chaperone GroES | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | aac(6')-aph(2'') | map / scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL | 2103277..2183486 | 80209 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12968.26 Da Isoelectric Point: 4.3050
>T212182 WP_001078344.1 NZ_CP080566:c2175507-2175181 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
Download Length: 327 bp
>T212182 NZ_CP106996:c4119378-4119028 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 62 a.a. Molecular weight: 7233.15 Da Isoelectric Point: 4.4184
>AT212182 WP_223200634.1 NZ_CP080566:c2175695-2175510 [Staphylococcus aureus]
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 186 bp
>AT212182 NZ_CP106996:c4119623-4119372 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|