115626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2044568..2044875 Replicon chromosome
Accession NZ_CP034259
Organism Staphylococcus aureus strain P1D12C1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EFD74_RS10075 Protein ID WP_011447039.1
Coordinates 2044699..2044875 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2044568..2044707 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD74_RS10035 2039913..2040173 + 261 WP_001791826.1 hypothetical protein -
EFD74_RS10040 2040226..2040576 - 351 WP_000702262.1 complement inhibitor SCIN-A -
EFD74_RS10045 2041259..2041708 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
EFD74_RS10050 2041803..2042137 - 335 Protein_1926 SH3 domain-containing protein -
EFD74_RS10055 2042784..2043275 - 492 WP_000920042.1 staphylokinase -
EFD74_RS10060 2043466..2044221 - 756 WP_002955266.1 CHAP domain-containing protein -
EFD74_RS10065 2044233..2044487 - 255 WP_000611512.1 phage holin -
EFD74_RS10070 2044539..2044646 + 108 WP_031762631.1 hypothetical protein -
- 2044568..2044707 + 140 NuclAT_0 - Antitoxin
- 2044568..2044707 + 140 NuclAT_0 - Antitoxin
- 2044568..2044707 + 140 NuclAT_0 - Antitoxin
- 2044568..2044707 + 140 NuclAT_0 - Antitoxin
EFD74_RS10075 2044699..2044875 - 177 WP_011447039.1 putative holin-like toxin Toxin
EFD74_RS10080 2045078..2045851 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
EFD74_RS10085 2046272..2046646 - 375 WP_000340977.1 hypothetical protein -
EFD74_RS10090 2046702..2046989 - 288 WP_001262621.1 hypothetical protein -
EFD74_RS10095 2047035..2047187 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2040226..2095431 55205


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T115626 WP_011447039.1 NZ_CP034259:c2044875-2044699 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T115626 NZ_CP034259:c2044875-2044699 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT115626 NZ_CP034259:2044568-2044707 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References