105203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2178386..2178693 Replicon chromosome
Accession NZ_CP029198
Organism Staphylococcus aureus strain aureus

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag FORC090_RS11120 Protein ID WP_011447039.1
Coordinates 2178517..2178693 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2178386..2178525 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC090_RS11070 2173732..2173992 + 261 WP_001791826.1 hypothetical protein -
FORC090_RS11075 2174045..2174395 - 351 WP_000702262.1 complement inhibitor SCIN-A -
FORC090_RS11080 2175077..2175526 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
FORC090_RS11085 2175621..2175955 - 335 Protein_2091 SH3 domain-containing protein -
FORC090_RS11100 2176602..2177093 - 492 WP_000920042.1 staphylokinase -
FORC090_RS11105 2177284..2178039 - 756 WP_138936766.1 CHAP domain-containing protein -
FORC090_RS11110 2178051..2178305 - 255 WP_000611512.1 phage holin -
FORC090_RS11115 2178357..2178464 + 108 WP_031762631.1 hypothetical protein -
- 2178386..2178525 + 140 NuclAT_0 - Antitoxin
- 2178386..2178525 + 140 NuclAT_0 - Antitoxin
- 2178386..2178525 + 140 NuclAT_0 - Antitoxin
- 2178386..2178525 + 140 NuclAT_0 - Antitoxin
FORC090_RS11120 2178517..2178693 - 177 WP_011447039.1 putative holin-like toxin Toxin
FORC090_RS11125 2178896..2179669 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
FORC090_RS11130 2179891..2181063 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
FORC090_RS11135 2181193..2182632 - 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
FORC090_RS11140 2182633..2183025 - 393 WP_000393259.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2174045..2247739 73694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T105203 WP_011447039.1 NZ_CP029198:c2178693-2178517 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T105203 NZ_CP029198:c2178693-2178517 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT105203 NZ_CP029198:2178386-2178525 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References