26627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2043900..2044207 Replicon chromosome
Accession NC_017340
Organism Staphylococcus aureus 04-02981

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SA2981_RS14780 Protein ID WP_011447039.1
Coordinates 2044031..2044207 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2043900..2044039 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA2981_RS10250 2039245..2039505 + 261 WP_001791826.1 hypothetical protein -
SA2981_RS10255 2039558..2039908 - 351 WP_000702262.1 complement inhibitor SCIN-A -
SA2981_RS10260 2040591..2041040 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
SA2981_RS10265 2041135..2041469 - 335 Protein_1938 SH3 domain-containing protein -
SA2981_RS10270 2042116..2042607 - 492 WP_000920042.1 staphylokinase -
SA2981_RS10275 2042798..2043553 - 756 WP_000861026.1 CHAP domain-containing protein -
SA2981_RS10280 2043565..2043819 - 255 WP_000611512.1 phage holin -
SA2981_RS10285 2043871..2043978 + 108 WP_031762631.1 hypothetical protein -
- 2043900..2044039 + 140 NuclAT_0 - Antitoxin
- 2043900..2044039 + 140 NuclAT_0 - Antitoxin
- 2043900..2044039 + 140 NuclAT_0 - Antitoxin
- 2043900..2044039 + 140 NuclAT_0 - Antitoxin
SA2981_RS14780 2044031..2044207 - 177 WP_011447039.1 putative holin-like toxin Toxin
SA2981_RS10295 2044410..2045183 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
SA2981_RS10300 2045604..2045978 - 375 WP_000340977.1 hypothetical protein -
SA2981_RS10305 2046034..2046321 - 288 WP_001262621.1 hypothetical protein -
SA2981_RS10310 2046367..2046519 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2039558..2094713 55155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T26627 WP_011447039.1 NC_017340:c2044207-2044031 [Staphylococcus aureus 04-02981]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T26627 NC_017340:c2044207-2044031 [Staphylococcus aureus 04-02981]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT26627 NC_017340:2043900-2044039 [Staphylococcus aureus 04-02981]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References