Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1956021..1956328 Replicon chromosome
Accession NC_017343
Organism Staphylococcus aureus subsp. aureus ECT-R 2

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag ECTR2_RS14325 Protein ID WP_011447039.1
Coordinates 1956152..1956328 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1956021..1956160 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTR2_RS09670 1951366..1951626 + 261 WP_001791826.1 hypothetical protein -
ECTR2_RS09675 1951679..1952029 - 351 WP_000702262.1 complement inhibitor SCIN-A -
ECTR2_RS09680 1952712..1953161 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
ECTR2_RS09685 1953256..1953590 - 335 Protein_1825 SH3 domain-containing protein -
ECTR2_RS09690 1954237..1954728 - 492 WP_000920042.1 staphylokinase -
ECTR2_RS09695 1954919..1955674 - 756 WP_000861026.1 CHAP domain-containing protein -
ECTR2_RS09700 1955686..1955940 - 255 WP_000611512.1 phage holin -
ECTR2_RS09705 1955992..1956099 + 108 WP_031762631.1 hypothetical protein -
- 1956021..1956160 + 140 NuclAT_0 - Antitoxin
- 1956021..1956160 + 140 NuclAT_0 - Antitoxin
- 1956021..1956160 + 140 NuclAT_0 - Antitoxin
- 1956021..1956160 + 140 NuclAT_0 - Antitoxin
ECTR2_RS14325 1956152..1956328 - 177 WP_011447039.1 putative holin-like toxin Toxin
ECTR2_RS09715 1956531..1957304 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
ECTR2_RS09720 1957725..1958099 - 375 WP_000340977.1 hypothetical protein -
ECTR2_RS09725 1958155..1958442 - 288 WP_001262621.1 hypothetical protein -
ECTR2_RS09730 1958488..1958640 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 1951679..2006832 55153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T26686 WP_011447039.1 NC_017343:c1956328-1956152 [Staphylococcus aureus subsp. aureus ECT-R 2]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T26686 NC_017343:c1956328-1956152 [Staphylococcus aureus subsp. aureus ECT-R 2]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT26686 NC_017343:1956021-1956160 [Staphylococcus aureus subsp. aureus ECT-R 2]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References