Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2242447..2242925 Replicon chromosome
Accession NZ_CP029198
Organism Staphylococcus aureus strain aureus

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag FORC090_RS11540 Protein ID WP_001078344.1
Coordinates 2242447..2242773 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag FORC090_RS11545 Protein ID WP_025175789.1
Coordinates 2242776..2242925 (-) Length 50 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC090_RS11515 2237671..2238012 - 342 WP_001190615.1 hypothetical protein -
FORC090_RS11520 2238462..2239103 - 642 WP_063663566.1 pathogenicity island protein -
FORC090_RS11525 2239100..2239480 - 381 WP_000356942.1 hypothetical protein -
FORC090_RS11530 2239790..2241499 - 1710 WP_138936772.1 DUF927 domain-containing protein -
FORC090_RS11535 2241513..2242382 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
FORC090_RS11540 2242447..2242773 - 327 WP_001078344.1 DUF1474 family protein Toxin
FORC090_RS11545 2242776..2242925 - 150 WP_025175789.1 hypothetical protein Antitoxin
FORC090_RS11550 2242978..2243124 - 147 WP_000784885.1 hypothetical protein -
FORC090_RS11555 2243121..2243438 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
FORC090_RS11560 2243443..2243661 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
FORC090_RS11565 2243834..2244508 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
FORC090_RS11570 2244522..2245694 + 1173 WP_000179343.1 site-specific integrase -
FORC090_RS11575 2245763..2247379 - 1617 WP_000240642.1 chaperonin GroEL -
FORC090_RS11580 2247455..2247739 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage aac(6')-aph(2'') scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2174045..2247739 73694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T105206 WP_001078344.1 NZ_CP029198:c2242773-2242447 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T105206 NZ_CP029198:c2242773-2242447 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 50 a.a.        Molecular weight: 5822.52 Da        Isoelectric Point: 4.4876

>AT105206 WP_025175789.1 NZ_CP029198:c2242925-2242776 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 150 bp

>AT105206 NZ_CP029198:c2242925-2242776 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure

References