Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | txpA-MW1433/- |
Location | 2044761..2045068 | Replicon | chromosome |
Accession | NZ_CP034011 | ||
Organism | Staphylococcus aureus strain P1D5C1 |
Toxin (Protein)
Gene name | txpA | Uniprot ID | Q2FWU9 |
Locus tag | EFD68_RS10075 | Protein ID | WP_011447039.1 |
Coordinates | 2044892..2045068 (-) | Length | 59 a.a. |
Antitoxin (RNA)
Gene name | MW1433 | ||
Locus tag | - | ||
Coordinates | 2044761..2044900 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EFD68_RS10035 | 2040106..2040366 | + | 261 | WP_001791826.1 | hypothetical protein | - |
EFD68_RS10040 | 2040419..2040769 | - | 351 | WP_000702262.1 | complement inhibitor SCIN-A | - |
EFD68_RS10045 | 2041452..2041901 | + | 450 | WP_000727645.1 | chemotaxis-inhibiting protein CHIPS | - |
EFD68_RS10050 | 2041996..2042330 | - | 335 | Protein_1926 | SH3 domain-containing protein | - |
EFD68_RS10055 | 2042977..2043468 | - | 492 | WP_000920042.1 | staphylokinase | - |
EFD68_RS10060 | 2043659..2044414 | - | 756 | WP_002955266.1 | CHAP domain-containing protein | - |
EFD68_RS10065 | 2044426..2044680 | - | 255 | WP_000611512.1 | phage holin | - |
EFD68_RS10070 | 2044732..2044839 | + | 108 | WP_031762631.1 | hypothetical protein | - |
- | 2044761..2044900 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2044761..2044900 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2044761..2044900 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2044761..2044900 | + | 140 | NuclAT_0 | - | Antitoxin |
EFD68_RS10075 | 2044892..2045068 | - | 177 | WP_011447039.1 | putative holin-like toxin | Toxin |
EFD68_RS10080 | 2045271..2046044 | - | 774 | WP_025174055.1 | staphylococcal enterotoxin type P | - |
EFD68_RS10085 | 2046465..2046839 | - | 375 | WP_000340977.1 | hypothetical protein | - |
EFD68_RS10090 | 2046895..2047182 | - | 288 | WP_001262621.1 | hypothetical protein | - |
EFD68_RS10095 | 2047228..2047380 | - | 153 | WP_001000058.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | scn / chp / sak / see / hlb / groEL | 2040419..2095624 | 55205 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T114929 WP_011447039.1 NZ_CP034011:c2045068-2044892 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T114929 NZ_CP034011:c2045068-2044892 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT114929 NZ_CP034011:2044761-2044900 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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