Detailed information of TA system TA212179

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2111118..2111425
• Replicon: chromosome
• Accession: NZ_CP080566
• Organism: Staphylococcus aureus strain HL20835 isolate HL20835

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: JMO16_RS10585
• Protein ID: WP_011447039.1
• Coordinates: 2111249..2111425 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2111118..2111257 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMO16_RS10545 (2106463)	2106463..2106723	+	261	WP_001791826.1	hypothetical protein	-
JMO16_RS10550 (2106776)	2106776..2107126	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
JMO16_RS10555 (2107809)	2107809..2108258	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
JMO16_RS10560 (2108353)	2108353..2108687	-	335	Protein_2061	SH3 domain-containing protein	-
JMO16_RS10565 (2109334)	2109334..2109825	-	492	WP_000920042.1	staphylokinase	-
JMO16_RS10570 (2110016)	2110016..2110771	-	756	WP_000861026.1	CHAP domain-containing protein	-
JMO16_RS10575 (2110783)	2110783..2111037	-	255	WP_000611512.1	phage holin	-
JMO16_RS10580 (2111089)	2111089..2111196	+	108	WP_031762631.1	hypothetical protein	-
- (2111118)	2111118..2111257	+	140	NuclAT_0	-	Antitoxin
- (2111118)	2111118..2111257	+	140	NuclAT_0	-	Antitoxin
- (2111118)	2111118..2111257	+	140	NuclAT_0	-	Antitoxin
- (2111118)	2111118..2111257	+	140	NuclAT_0	-	Antitoxin
JMO16_RS10585 (2111249)	2111249..2111425	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
JMO16_RS10590 (2111628)	2111628..2112401	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
JMO16_RS10595 (2112623)	2112623..2113795	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
JMO16_RS10600 (2113925)	2113925..2115364	-	1440	WP_001028144.1	aminoglycoside O-phosphotransferase APH(2'')-Ia	-
JMO16_RS10605 (2115365)	2115365..2115757	-	393	WP_000393259.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002745 Staphylococcus aureus subsp. aureus N315 Prophage TA006360, TA010116, TA020387 2006528..2074317 0.004	inside	Prophage	aac(6')-aph(2'')	map / scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL	2103277..2183486	80209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212179 WP_011447039.1 NZ_CP080566:c2111425-2111249 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212179 NZ_CP106996:c3753913-3753515 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT212179 NZ_CP080566:2111118-2111257 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin