53045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2009053..2009360 Replicon chromosome
Accession NZ_CP010890
Organism Staphylococcus aureus strain SA564

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RT87_RS14615 Protein ID WP_011447039.1
Coordinates 2009184..2009360 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2009053..2009192 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RT87_RS10035 2004398..2004658 + 261 WP_001791826.1 hypothetical protein -
RT87_RS10040 2004711..2005061 - 351 WP_000702262.1 complement inhibitor SCIN-A -
RT87_RS10045 2005744..2006193 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
RT87_RS10050 2006288..2006622 - 335 Protein_1897 SH3 domain-containing protein -
RT87_RS10055 2007269..2007760 - 492 WP_000920042.1 staphylokinase -
RT87_RS10060 2007951..2008706 - 756 WP_000861026.1 CHAP domain-containing protein -
RT87_RS10065 2008718..2008972 - 255 WP_000611512.1 phage holin -
RT87_RS10070 2009024..2009131 + 108 WP_031762631.1 hypothetical protein -
- 2009053..2009192 + 140 NuclAT_0 - Antitoxin
- 2009053..2009192 + 140 NuclAT_0 - Antitoxin
- 2009053..2009192 + 140 NuclAT_0 - Antitoxin
- 2009053..2009192 + 140 NuclAT_0 - Antitoxin
RT87_RS14615 2009184..2009360 - 177 WP_011447039.1 putative holin-like toxin Toxin
RT87_RS10075 2009563..2010336 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
RT87_RS10080 2010757..2011131 - 375 WP_000340977.1 hypothetical protein -
RT87_RS10085 2011187..2011474 - 288 WP_001262621.1 hypothetical protein -
RT87_RS10090 2011520..2011672 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2004711..2056839 52128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T53045 WP_011447039.1 NZ_CP010890:c2009360-2009184 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T53045 NZ_CP010890:c2009360-2009184 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT53045 NZ_CP010890:2009053-2009192 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References