265259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 392680..393194 Replicon chromosome
Accession NZ_CP113039
Organism Staphylococcus aureus strain Gwen

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag OS086_RS02190 Protein ID WP_001078344.1
Coordinates 392680..393006 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag OS086_RS02195 Protein ID WP_223200634.1
Coordinates 393009..393194 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS086_RS02165 (387904) 387904..388245 - 342 WP_001190615.1 hypothetical protein -
OS086_RS02170 (388695) 388695..389336 - 642 WP_001047698.1 hypothetical protein -
OS086_RS02175 (389333) 389333..389713 - 381 WP_000356942.1 hypothetical protein -
OS086_RS02180 (390023) 390023..391732 - 1710 Protein_398 DUF927 domain-containing protein -
OS086_RS02185 (391746) 391746..392615 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
OS086_RS02190 (392680) 392680..393006 - 327 WP_001078344.1 DUF1474 family protein Toxin
OS086_RS02195 (393009) 393009..393194 - 186 WP_223200634.1 pathogenicity island protein Antitoxin
OS086_RS02200 (393211) 393211..393357 - 147 WP_000784885.1 hypothetical protein -
OS086_RS02205 (393354) 393354..393671 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
OS086_RS02210 (393676) 393676..393894 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
OS086_RS02215 (394067) 394067..394741 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
OS086_RS02220 (394755) 394755..395927 + 1173 WP_000179343.1 tyrosine-type recombinase/integrase -
OS086_RS02225 (395996) 395996..397612 - 1617 WP_000240642.1 chaperonin GroEL -
OS086_RS02230 (397688) 397688..397972 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 330182..397972 67790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T265259 WP_001078344.1 NZ_CP113039:c393006-392680 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 7233.15 Da        Isoelectric Point: 4.4184

>AT265259 WP_223200634.1 NZ_CP113039:c393194-393009 [Staphylococcus aureus]
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure

References