Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | txpA-MW1433/- |
Location | 2113802..2114109 | Replicon | chromosome |
Accession | NZ_AP019543 | ||
Organism | Staphylococcus aureus strain KG-18 |
Toxin (Protein)
Gene name | txpA | Uniprot ID | Q2FWU9 |
Locus tag | GDK18_RS10650 | Protein ID | WP_011447039.1 |
Coordinates | 2113933..2114109 (-) | Length | 59 a.a. |
Antitoxin (RNA)
Gene name | MW1433 | ||
Locus tag | - | ||
Coordinates | 2113802..2113941 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GDK18_RS10600 | 2109147..2109407 | + | 261 | WP_001791826.1 | hypothetical protein | - |
GDK18_RS10605 | 2109460..2109810 | - | 351 | WP_000702262.1 | complement inhibitor SCIN-A | - |
GDK18_RS10610 | 2110493..2110942 | + | 450 | WP_000727645.1 | chemotaxis-inhibiting protein CHIPS | - |
GDK18_RS10615 | 2111037..2111371 | - | 335 | Protein_2000 | SH3 domain-containing protein | - |
GDK18_RS10630 | 2112018..2112509 | - | 492 | WP_000920042.1 | staphylokinase | - |
GDK18_RS10635 | 2112700..2113455 | - | 756 | WP_000861026.1 | CHAP domain-containing protein | - |
GDK18_RS10640 | 2113467..2113721 | - | 255 | WP_000611512.1 | phage holin | - |
GDK18_RS10645 | 2113773..2113880 | + | 108 | WP_031762631.1 | hypothetical protein | - |
- | 2113802..2113941 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2113802..2113941 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2113802..2113941 | + | 140 | NuclAT_0 | - | Antitoxin |
- | 2113802..2113941 | + | 140 | NuclAT_0 | - | Antitoxin |
GDK18_RS10650 | 2113933..2114109 | - | 177 | WP_011447039.1 | putative holin-like toxin | Toxin |
GDK18_RS10655 | 2114312..2115085 | - | 774 | WP_025174055.1 | staphylococcal enterotoxin type P | - |
GDK18_RS10660 | 2115506..2115880 | - | 375 | WP_000340977.1 | hypothetical protein | - |
GDK18_RS10665 | 2115936..2116223 | - | 288 | WP_001262621.1 | hypothetical protein | - |
GDK18_RS10670 | 2116269..2116421 | - | 153 | WP_001000058.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | map / hlb / scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL | 2105961..2178582 | 72621 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T32721 WP_011447039.1 NZ_AP019543:c2114109-2113933 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T32721 NZ_AP019543:c2114109-2113933 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 140 bp
>AT32721 NZ_AP019543:2113802-2113941 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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