Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2091312..2091619 Replicon chromosome
Accession NZ_CP033987
Organism Staphylococcus aureus strain P2D1C1

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EFD76_RS10485 Protein ID WP_011447039.1
Coordinates 2091443..2091619 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2091312..2091451 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD76_RS10445 2086657..2086917 + 261 WP_001791826.1 hypothetical protein -
EFD76_RS10450 2086970..2087320 - 351 WP_000702262.1 complement inhibitor SCIN-A -
EFD76_RS10455 2088003..2088452 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
EFD76_RS10460 2088547..2088881 - 335 Protein_1981 SH3 domain-containing protein -
EFD76_RS10465 2089528..2090019 - 492 WP_000920042.1 staphylokinase -
EFD76_RS10470 2090210..2090965 - 756 WP_002955266.1 CHAP domain-containing protein -
EFD76_RS10475 2090977..2091231 - 255 WP_000611512.1 phage holin -
EFD76_RS10480 2091283..2091390 + 108 WP_031762631.1 hypothetical protein -
- 2091312..2091451 + 140 NuclAT_0 - Antitoxin
- 2091312..2091451 + 140 NuclAT_0 - Antitoxin
- 2091312..2091451 + 140 NuclAT_0 - Antitoxin
- 2091312..2091451 + 140 NuclAT_0 - Antitoxin
EFD76_RS10485 2091443..2091619 - 177 WP_011447039.1 putative holin-like toxin Toxin
EFD76_RS10490 2091822..2092595 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
EFD76_RS10495 2093016..2093390 - 375 WP_000340977.1 hypothetical protein -
EFD76_RS10500 2093446..2093733 - 288 WP_001262621.1 hypothetical protein -
EFD76_RS10505 2093779..2093931 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2086970..2139150 52180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T114803 WP_011447039.1 NZ_CP033987:c2091619-2091443 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T114803 NZ_CP033987:c2091619-2091443 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT114803 NZ_CP033987:2091312-2091451 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References