293103

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2056634..2056941 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag NZAK3_RS14955 Protein ID WP_011447039.1
Coordinates 2056765..2056941 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2056634..2056773 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS10375 2051979..2052239 + 261 WP_001791826.1 hypothetical protein -
NZAK3_RS10380 2052292..2052642 - 351 WP_000702262.1 complement inhibitor SCIN-A -
NZAK3_RS10385 2053325..2053774 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
NZAK3_RS10390 2053869..2054203 - 335 Protein_1963 SH3 domain-containing protein -
NZAK3_RS10395 2054850..2055341 - 492 WP_000920042.1 staphylokinase -
NZAK3_RS10400 2055532..2056287 - 756 WP_000861026.1 CHAP domain-containing protein -
NZAK3_RS10405 2056299..2056553 - 255 WP_000611512.1 phage holin -
NZAK3_RS10410 2056605..2056712 + 108 WP_031762631.1 hypothetical protein -
- 2056634..2056773 + 140 NuclAT_0 - Antitoxin
- 2056634..2056773 + 140 NuclAT_0 - Antitoxin
- 2056634..2056773 + 140 NuclAT_0 - Antitoxin
- 2056634..2056773 + 140 NuclAT_0 - Antitoxin
NZAK3_RS14955 2056765..2056941 - 177 WP_011447039.1 putative holin-like toxin Toxin
NZAK3_RS10415 2057144..2057917 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
NZAK3_RS10420 2058338..2058712 - 375 WP_000340977.1 hypothetical protein -
NZAK3_RS10425 2058768..2059055 - 288 WP_001262621.1 hypothetical protein -
NZAK3_RS10430 2059101..2059253 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2052292..2104420 52128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T293103 WP_011447039.1 NZ_LT009690:c2056941-2056765 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 140 bp

>AT293103 NZ_LT009690:2056634-2056773 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References