106258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2055189..2055496 Replicon chromosome
Accession NZ_CP029673
Organism Staphylococcus aureus strain AR_0220

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag CSB76_RS10695 Protein ID WP_011447039.1
Coordinates 2055320..2055496 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2055189..2055328 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB76_RS10645 2050534..2050794 + 261 WP_001791826.1 hypothetical protein -
CSB76_RS10650 2050847..2051197 - 351 WP_000702262.1 complement inhibitor SCIN-A -
CSB76_RS10655 2051880..2052329 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
CSB76_RS10660 2052424..2052758 - 335 Protein_1933 SH3 domain-containing protein -
CSB76_RS10675 2053405..2053896 - 492 WP_000920042.1 staphylokinase -
CSB76_RS10680 2054087..2054842 - 756 WP_000861026.1 CHAP domain-containing protein -
CSB76_RS10685 2054854..2055108 - 255 WP_000611512.1 phage holin -
CSB76_RS10690 2055160..2055267 + 108 WP_031762631.1 hypothetical protein -
- 2055189..2055328 + 140 NuclAT_0 - Antitoxin
- 2055189..2055328 + 140 NuclAT_0 - Antitoxin
- 2055189..2055328 + 140 NuclAT_0 - Antitoxin
- 2055189..2055328 + 140 NuclAT_0 - Antitoxin
CSB76_RS10695 2055320..2055496 - 177 WP_011447039.1 putative holin-like toxin Toxin
CSB76_RS10700 2055699..2056472 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
CSB76_RS10705 2056893..2057267 - 375 WP_000340977.1 hypothetical protein -
CSB76_RS10710 2057323..2057610 - 288 WP_001262621.1 hypothetical protein -
CSB76_RS10715 2057656..2057808 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2050847..2105942 55095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T106258 WP_011447039.1 NZ_CP029673:c2055496-2055320 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T106258 NZ_CP029673:c2055496-2055320 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT106258 NZ_CP029673:2055189-2055328 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References