Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2173290..2173768 Replicon chromosome
Accession NZ_AP019543
Organism Staphylococcus aureus strain KG-18

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag GDK18_RS11050 Protein ID WP_001078344.1
Coordinates 2173290..2173616 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag GDK18_RS11055 Protein ID WP_025175789.1
Coordinates 2173619..2173768 (-) Length 50 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK18_RS11025 2168514..2168855 - 342 WP_001190615.1 hypothetical protein -
GDK18_RS11030 2169305..2169946 - 642 WP_001047698.1 hypothetical protein -
GDK18_RS11035 2169943..2170323 - 381 WP_000356942.1 hypothetical protein -
GDK18_RS11040 2170633..2172342 - 1710 WP_000447473.1 DUF927 domain-containing protein -
GDK18_RS11045 2172356..2173225 - 870 WP_152064758.1 primase alpha helix C-terminal domain-containing protein -
GDK18_RS11050 2173290..2173616 - 327 WP_001078344.1 DUF1474 family protein Toxin
GDK18_RS11055 2173619..2173768 - 150 WP_025175789.1 hypothetical protein Antitoxin
GDK18_RS11060 2173821..2173967 - 147 WP_000784885.1 hypothetical protein -
GDK18_RS11065 2173964..2174281 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
GDK18_RS11070 2174286..2174504 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
GDK18_RS11075 2174677..2175351 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
GDK18_RS11080 2175365..2176537 + 1173 WP_000179343.1 site-specific integrase -
GDK18_RS11085 2176606..2178222 - 1617 WP_000240642.1 chaperonin GroEL -
GDK18_RS11090 2178298..2178582 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2105961..2178582 72621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T32724 WP_001078344.1 NZ_AP019543:c2173616-2173290 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T32724 NZ_AP019543:c2173616-2173290 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 50 a.a.        Molecular weight: 5822.52 Da        Isoelectric Point: 4.4876

>AT32724 WP_025175789.1 NZ_AP019543:c2173768-2173619 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 150 bp

>AT32724 NZ_AP019543:c2173768-2173619 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure

References