75974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1959330..1959637 Replicon chromosome
Accession NZ_CP021105
Organism Staphylococcus aureus strain CC5

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag B4893_RS10010 Protein ID WP_011447039.1
Coordinates 1959461..1959637 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1959330..1959469 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4893_RS09960 1954671..1954931 + 261 WP_001791826.1 hypothetical protein -
B4893_RS09965 1954984..1955334 - 351 WP_000702262.1 complement inhibitor SCIN-A -
B4893_RS09970 1956017..1956466 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
B4893_RS09975 1956561..1956895 - 335 Protein_1832 SH3 domain-containing protein -
B4893_RS09990 1957542..1958033 - 492 WP_000920042.1 staphylokinase -
B4893_RS09995 1958228..1958983 - 756 WP_000861038.1 CHAP domain-containing protein -
B4893_RS10000 1958995..1959249 - 255 WP_000611512.1 phage holin -
B4893_RS10005 1959301..1959408 + 108 WP_031762631.1 hypothetical protein -
- 1959330..1959469 + 140 NuclAT_0 - Antitoxin
- 1959330..1959469 + 140 NuclAT_0 - Antitoxin
- 1959330..1959469 + 140 NuclAT_0 - Antitoxin
- 1959330..1959469 + 140 NuclAT_0 - Antitoxin
B4893_RS10010 1959461..1959637 - 177 WP_011447039.1 putative holin-like toxin Toxin
B4893_RS10015 1959840..1960613 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
B4893_RS10020 1961034..1961408 - 375 WP_000340977.1 hypothetical protein -
B4893_RS10025 1961464..1961751 - 288 WP_001262621.1 hypothetical protein -
B4893_RS10030 1961797..1961949 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 1954984..2018119 63135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T75974 WP_011447039.1 NZ_CP021105:c1959637-1959461 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T75974 NZ_CP021105:c1959637-1959461 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT75974 NZ_CP021105:1959330-1959469 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References