93223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1618656..1619194 Replicon chromosome
Accession NZ_CP026079
Organism Staphylococcus aureus strain FDAARGOS_9

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag RK67_RS08280 Protein ID WP_001078344.1
Coordinates 1618868..1619194 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag RK67_RS08275 Protein ID WP_001058495.1
Coordinates 1618656..1618865 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK67_RS08240 1613902..1614186 + 285 WP_000917289.1 co-chaperone GroES -
RK67_RS08245 1614262..1615878 + 1617 WP_000240642.1 chaperonin GroEL -
RK67_RS08250 1615947..1617119 - 1173 WP_000179343.1 site-specific integrase -
RK67_RS08255 1617133..1617807 - 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
RK67_RS08260 1617980..1618198 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
RK67_RS08265 1618203..1618520 + 318 WP_000481967.1 helix-turn-helix domain-containing protein -
RK67_RS08270 1618517..1618663 + 147 WP_000784885.1 hypothetical protein -
RK67_RS08275 1618656..1618865 + 210 WP_001058495.1 hypothetical protein Antitoxin
RK67_RS08280 1618868..1619194 + 327 WP_001078344.1 DUF1474 family protein Toxin
RK67_RS08285 1619259..1620128 + 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
RK67_RS08290 1620142..1621851 + 1710 WP_000447473.1 DUF927 domain-containing protein -
RK67_RS08295 1622161..1622541 + 381 WP_000356942.1 hypothetical protein -
RK67_RS08300 1622538..1623179 + 642 WP_001047698.1 hypothetical protein -
RK67_RS08305 1623629..1623970 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / tsst-1 / sec / sell / hlb / see / sak / chp / scn 1613902..1681691 67789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T93223 WP_001078344.1 NZ_CP026079:1618868-1619194 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T93223 NZ_CP026079:1618868-1619194 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT93223 WP_001058495.1 NZ_CP026079:1618656-1618865 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT93223 NZ_CP026079:1618656-1618865 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References