70417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2127589..2127896 Replicon chromosome
Accession NZ_CP018766
Organism Staphylococcus aureus strain UCI62

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag BSG38_RS11085 Protein ID WP_011447039.1
Coordinates 2127720..2127896 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2127589..2127728 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG38_RS11035 2122934..2123194 + 261 WP_001791826.1 hypothetical protein -
BSG38_RS11040 2123247..2123597 - 351 WP_000702262.1 complement inhibitor SCIN-A -
BSG38_RS11045 2124280..2124729 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
BSG38_RS11050 2124824..2125158 - 335 Protein_2036 SH3 domain-containing protein -
BSG38_RS11065 2125805..2126296 - 492 WP_000920042.1 staphylokinase -
BSG38_RS11070 2126487..2127242 - 756 WP_000861027.1 CHAP domain-containing protein -
BSG38_RS11075 2127254..2127508 - 255 WP_000611512.1 phage holin -
BSG38_RS11080 2127560..2127667 + 108 WP_031762631.1 hypothetical protein -
- 2127589..2127728 + 140 NuclAT_0 - Antitoxin
- 2127589..2127728 + 140 NuclAT_0 - Antitoxin
- 2127589..2127728 + 140 NuclAT_0 - Antitoxin
- 2127589..2127728 + 140 NuclAT_0 - Antitoxin
BSG38_RS11085 2127720..2127896 - 177 WP_011447039.1 putative holin-like toxin Toxin
BSG38_RS11090 2128099..2128872 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
BSG38_RS11095 2129293..2129667 - 375 WP_000340977.1 hypothetical protein -
BSG38_RS11100 2129723..2130010 - 288 WP_001262621.1 hypothetical protein -
BSG38_RS11105 2130056..2130208 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2123247..2175374 52127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T70417 WP_011447039.1 NZ_CP018766:c2127896-2127720 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T70417 NZ_CP018766:c2127896-2127720 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT70417 NZ_CP018766:2127589-2127728 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References