Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2111819..2112126 Replicon chromosome
Accession NZ_AP019545
Organism Staphylococcus aureus strain KG-22

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag GDK20_RS10650 Protein ID WP_011447039.1
Coordinates 2111950..2112126 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2111819..2111958 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK20_RS10600 2107164..2107424 + 261 WP_001791826.1 hypothetical protein -
GDK20_RS10605 2107477..2107827 - 351 WP_000702262.1 complement inhibitor SCIN-A -
GDK20_RS10610 2108510..2108959 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
GDK20_RS10615 2109054..2109388 - 335 Protein_2003 SH3 domain-containing protein -
GDK20_RS10630 2110035..2110526 - 492 WP_000920042.1 staphylokinase -
GDK20_RS10635 2110717..2111472 - 756 WP_000861026.1 CHAP domain-containing protein -
GDK20_RS10640 2111484..2111738 - 255 WP_000611512.1 phage holin -
GDK20_RS10645 2111790..2111897 + 108 WP_031762631.1 hypothetical protein -
- 2111819..2111958 + 140 NuclAT_0 - Antitoxin
- 2111819..2111958 + 140 NuclAT_0 - Antitoxin
- 2111819..2111958 + 140 NuclAT_0 - Antitoxin
- 2111819..2111958 + 140 NuclAT_0 - Antitoxin
GDK20_RS10650 2111950..2112126 - 177 WP_011447039.1 putative holin-like toxin Toxin
GDK20_RS10655 2112429..2113601 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
GDK20_RS10665 2113679..2114434 - 756 WP_172964119.1 staphylococcal enterotoxin type P -
GDK20_RS10670 2114694..2115866 + 1173 WP_000195429.1 IS256-like element IS256 family transposase -
GDK20_RS10675 2116187..2116561 - 375 WP_000340977.1 hypothetical protein -
GDK20_RS10680 2116617..2116904 - 288 WP_001262621.1 hypothetical protein -
GDK20_RS10685 2116950..2117102 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2107477..2177931 70454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T32743 WP_011447039.1 NZ_AP019545:c2112126-2111950 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T32743 NZ_AP019545:c2112126-2111950 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT32743 NZ_AP019545:2111819-2111958 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References