Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2103991..2104298 Replicon chromosome
Accession NZ_AP019542
Organism Staphylococcus aureus strain KG-03

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag GDK21_RS10610 Protein ID WP_011447039.1
Coordinates 2104122..2104298 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2103991..2104130 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK21_RS10560 2099336..2099596 + 261 WP_001791826.1 hypothetical protein -
GDK21_RS10565 2099649..2099999 - 351 WP_000702262.1 complement inhibitor SCIN-A -
GDK21_RS10570 2100682..2101131 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
GDK21_RS10575 2101226..2101560 - 335 Protein_1996 SH3 domain-containing protein -
GDK21_RS10590 2102207..2102698 - 492 WP_000920042.1 staphylokinase -
GDK21_RS10595 2102889..2103644 - 756 WP_000861026.1 CHAP domain-containing protein -
GDK21_RS10600 2103656..2103910 - 255 WP_000611512.1 phage holin -
GDK21_RS10605 2103962..2104069 + 108 WP_031762631.1 hypothetical protein -
- 2103991..2104130 + 140 NuclAT_0 - Antitoxin
- 2103991..2104130 + 140 NuclAT_0 - Antitoxin
- 2103991..2104130 + 140 NuclAT_0 - Antitoxin
- 2103991..2104130 + 140 NuclAT_0 - Antitoxin
GDK21_RS10610 2104122..2104298 - 177 WP_011447039.1 putative holin-like toxin Toxin
GDK21_RS10615 2104501..2105274 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
GDK21_RS10620 2105695..2106069 - 375 WP_000340977.1 hypothetical protein -
GDK21_RS10625 2106125..2106412 - 288 WP_001262621.1 hypothetical protein -
GDK21_RS10630 2106458..2106610 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2096150..2167439 71289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T32699 WP_011447039.1 NZ_AP019542:c2104298-2104122 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T32699 NZ_AP019542:c2104298-2104122 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT32699 NZ_AP019542:2103991-2104130 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References