68021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2011414..2011721 Replicon chromosome
Accession NZ_CP017682
Organism Staphylococcus aureus strain CFSAN007850

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag AB526_RS10285 Protein ID WP_011447039.1
Coordinates 2011545..2011721 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2011414..2011553 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB526_RS10235 2006759..2007019 + 261 WP_001791826.1 hypothetical protein -
AB526_RS10240 2007072..2007422 - 351 WP_000702262.1 complement inhibitor SCIN-A -
AB526_RS10245 2008105..2008554 + 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
AB526_RS10250 2008649..2008983 - 335 Protein_1903 SH3 domain-containing protein -
AB526_RS10265 2009630..2010121 - 492 WP_000920042.1 staphylokinase -
AB526_RS10270 2010312..2011067 - 756 WP_000861026.1 CHAP domain-containing protein -
AB526_RS10275 2011079..2011333 - 255 WP_000611512.1 phage holin -
AB526_RS10280 2011385..2011492 + 108 WP_031762631.1 hypothetical protein -
- 2011414..2011553 + 140 NuclAT_0 - Antitoxin
- 2011414..2011553 + 140 NuclAT_0 - Antitoxin
- 2011414..2011553 + 140 NuclAT_0 - Antitoxin
- 2011414..2011553 + 140 NuclAT_0 - Antitoxin
AB526_RS10285 2011545..2011721 - 177 WP_011447039.1 putative holin-like toxin Toxin
AB526_RS10290 2011924..2012697 - 774 WP_025174055.1 staphylococcal enterotoxin type P -
AB526_RS10295 2013118..2013492 - 375 WP_000340977.1 hypothetical protein -
AB526_RS10300 2013548..2013835 - 288 WP_001262621.1 hypothetical protein -
AB526_RS10305 2013881..2014033 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / groEL 2007072..2057892 50820


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T68021 WP_011447039.1 NZ_CP017682:c2011721-2011545 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T68021 NZ_CP017682:c2011721-2011545 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT68021 NZ_CP017682:2011414-2011553 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References