32746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2172639..2173117 Replicon chromosome
Accession NZ_AP019545
Organism Staphylococcus aureus strain KG-22

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag GDK20_RS11055 Protein ID WP_001078344.1
Coordinates 2172639..2172965 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag GDK20_RS11060 Protein ID WP_025175789.1
Coordinates 2172968..2173117 (-) Length 50 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK20_RS11030 2167863..2168204 - 342 WP_001190615.1 hypothetical protein -
GDK20_RS11035 2168654..2169295 - 642 WP_001047698.1 hypothetical protein -
GDK20_RS11040 2169292..2169672 - 381 WP_000356942.1 hypothetical protein -
GDK20_RS11045 2169982..2171691 - 1710 WP_000447473.1 DUF927 domain-containing protein -
GDK20_RS11050 2171705..2172574 - 870 WP_152064758.1 primase alpha helix C-terminal domain-containing protein -
GDK20_RS11055 2172639..2172965 - 327 WP_001078344.1 DUF1474 family protein Toxin
GDK20_RS11060 2172968..2173117 - 150 WP_025175789.1 hypothetical protein Antitoxin
GDK20_RS11065 2173170..2173316 - 147 WP_000784885.1 hypothetical protein -
GDK20_RS11070 2173313..2173630 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
GDK20_RS11075 2173635..2173853 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
GDK20_RS11080 2174026..2174700 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
GDK20_RS11085 2174714..2175886 + 1173 WP_000179343.1 site-specific integrase -
GDK20_RS11090 2175955..2177571 - 1617 WP_000240642.1 chaperonin GroEL -
GDK20_RS11095 2177647..2177931 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / chp / sak / see / hlb / sell / sec / tsst-1 / groEL 2107477..2177931 70454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T32746 WP_001078344.1 NZ_AP019545:c2172965-2172639 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T32746 NZ_AP019545:c2172965-2172639 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 50 a.a.        Molecular weight: 5822.52 Da        Isoelectric Point: 4.4876

>AT32746 WP_025175789.1 NZ_AP019545:c2173117-2172968 [Staphylococcus aureus]
VNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 150 bp

>AT32746 NZ_AP019545:c2173117-2172968 [Staphylococcus aureus]
GTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCA
CTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure

References