Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type I Classification (family/domain) /-
Location 2051171..2051347 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag MW_RS14845 Protein ID WP_011447039.1
Coordinates 2051171..2051347 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name -
Locus tag -
Coordinates - ()

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS10250 (MW1882) 2046605..2046784 + 180 WP_000669791.1 hypothetical protein -
MW_RS10260 2047095..2047355 + 261 WP_001791826.1 hypothetical protein -
MW_RS10265 (MW1884) 2047408..2047758 - 351 WP_000702263.1 complement inhibitor SCIN-A -
MW_RS10270 2048270..2048605 - 336 Protein_1935 SH3 domain-containing protein -
MW_RS10280 (MW1885) 2049256..2049747 - 492 WP_000920039.1 staphylokinase -
MW_RS10285 (MW1886) 2049938..2050693 - 756 WP_000861038.1 CHAP domain-containing protein -
MW_RS10290 (MW1887) 2050705..2050959 - 255 WP_000611512.1 phage holin -
MW_RS10295 2051011..2051118 + 108 WP_031762631.1 hypothetical protein -
MW_RS14845 2051171..2051347 - 177 WP_011447039.1 putative holin-like toxin Toxin
MW_RS10305 (MW1889) 2051456..2052229 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
MW_RS10310 (MW1890) 2052602..2052976 - 375 WP_000340977.1 hypothetical protein -
MW_RS10315 (MW1891) 2053032..2053319 - 288 WP_001262624.1 hypothetical protein -
MW_RS10320 (MW1892) 2053365..2053517 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2047408..2102909 55501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T10154 WP_011447039.1 NC_003923:c2051347-2051171 [Staphylococcus aureus subsp. aureus MW2]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T10154 NC_003923:c2051347-2051171 [Staphylococcus aureus subsp. aureus MW2]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 1 bp

>AT10154 UFRD01000002:c3092991-3092698 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References

(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856] experimental


experimental experimental literature