Detailed information of TA system
Experimentally validatedOverview
TA module
Type | I | Classification (family/domain) | /- |
Location | 2051171..2051347 | Replicon | chromosome |
Accession | NC_003923 | ||
Organism | Staphylococcus aureus subsp. aureus MW2 |
Toxin (Protein)
Gene name | txpA | Uniprot ID | Q2FWU9 |
Locus tag | MW_RS14845 | Protein ID | WP_011447039.1 |
Coordinates | 2051171..2051347 (-) | Length | 59 a.a. |
Antitoxin (RNA)
Gene name | - | ||
Locus tag | - | ||
Coordinates | - () |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MW_RS10250 (MW1882) | 2046605..2046784 | + | 180 | WP_000669791.1 | hypothetical protein | - |
MW_RS10260 | 2047095..2047355 | + | 261 | WP_001791826.1 | hypothetical protein | - |
MW_RS10265 (MW1884) | 2047408..2047758 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
MW_RS10270 | 2048270..2048605 | - | 336 | Protein_1935 | SH3 domain-containing protein | - |
MW_RS10280 (MW1885) | 2049256..2049747 | - | 492 | WP_000920039.1 | staphylokinase | - |
MW_RS10285 (MW1886) | 2049938..2050693 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
MW_RS10290 (MW1887) | 2050705..2050959 | - | 255 | WP_000611512.1 | phage holin | - |
MW_RS10295 | 2051011..2051118 | + | 108 | WP_031762631.1 | hypothetical protein | - |
MW_RS14845 | 2051171..2051347 | - | 177 | WP_011447039.1 | putative holin-like toxin | Toxin |
MW_RS10305 (MW1889) | 2051456..2052229 | - | 774 | WP_000750412.1 | staphylococcal enterotoxin type A | - |
MW_RS10310 (MW1890) | 2052602..2052976 | - | 375 | WP_000340977.1 | hypothetical protein | - |
MW_RS10315 (MW1891) | 2053032..2053319 | - | 288 | WP_001262624.1 | hypothetical protein | - |
MW_RS10320 (MW1892) | 2053365..2053517 | - | 153 | WP_001000058.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | scn / sak / sea / selq / selk / hlb / groEL | 2047408..2102909 | 55501 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T10154 WP_011447039.1 NC_003923:c2051347-2051171 [Staphylococcus aureus subsp. aureus MW2]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T10154 NC_003923:c2051347-2051171 [Staphylococcus aureus subsp. aureus MW2]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 1 bp
>AT10154 UFRD01000002:c3092991-3092698 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T10146 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_5 |
100 |
100 |
1 |
T6360 | Staphylococcus aureus subsp. aureus N315 |
100 |
100 |
1 |
T10025 | Staphylococcus aureus subsp. aureus N315 |
56 |
100 |
0.56 |
T10204 | Enterococcus faecalis V583 |
55.172 |
85.294 |
0.471 |
T10049 | Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9 |
56 |
71.429 |
0.4 |
T10207 | Enterococcus faecalis V583 |
36 |
96.154 |
0.346 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
References
(1) Gul Habib et al. (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins 10(11):473. [PubMed:30441856]
experimental literature