116045

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2182655..2182993 Replicon chromosome
Accession NZ_CP034441
Organism Staphylococcus aureus strain PMB 81-4

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag EJN89_RS11265 Protein ID WP_011447039.1
Coordinates 2182655..2182831 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2182819..2182993 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN89_RS11245 2180485..2180637 + 153 WP_001000058.1 hypothetical protein -
EJN89_RS11250 2180683..2180970 + 288 WP_001262621.1 hypothetical protein -
EJN89_RS11255 2181026..2181400 + 375 WP_000340977.1 hypothetical protein -
EJN89_RS11260 2181773..2182546 + 774 WP_000750412.1 staphylococcal enterotoxin type A -
EJN89_RS11265 2182655..2182831 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 2182819..2182993 - 175 - - Antitoxin
EJN89_RS11275 2183043..2183297 + 255 WP_000611512.1 phage holin -
EJN89_RS11280 2183309..2184064 + 756 WP_000861025.1 CHAP domain-containing protein -
EJN89_RS11285 2184255..2184746 + 492 WP_000920038.1 staphylokinase -
EJN89_RS11305 2185397..2185732 + 336 Protein_2103 SH3 domain-containing protein -
EJN89_RS11310 2186243..2186593 + 351 WP_000702263.1 complement inhibitor SCIN-A -
EJN89_RS11315 2186646..2186906 - 261 WP_001791826.1 hypothetical protein -
EJN89_RS11325 2187217..2187396 - 180 WP_000669791.1 hypothetical protein -
EJN89_RS11330 2187718..2187968 - 251 Protein_2107 sphingomyelin phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - selk / selq / sea / sak / scn 2145262..2186593 41331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T116045 WP_011447039.1 NZ_CP034441:2182655-2182831 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T116045 NZ_CP034441:2182655-2182831 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 175 bp

>AT116045 NZ_CP034441:c2182993-2182819 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References