39259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2085704..2086011 Replicon chromosome
Accession NZ_AP024723
Organism Staphylococcus aureus strain 59458

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX22_RS10375 Protein ID WP_011447039.1
Coordinates 2085835..2086011 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2085704..2085843 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX22_RS10330 (2080704) 2080704..2080901 + 198 WP_000239610.1 phospholipase -
OCX22_RS10335 (2081273) 2081273..2081452 + 180 WP_000669791.1 hypothetical protein -
OCX22_RS10340 (2081763) 2081763..2082023 + 261 WP_001791826.1 hypothetical protein -
OCX22_RS10345 (2082076) 2082076..2082426 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX22_RS10350 (2082938) 2082938..2083273 - 336 Protein_2001 SH3 domain-containing protein -
OCX22_RS10355 (2083924) 2083924..2084415 - 492 WP_000920038.1 staphylokinase -
OCX22_RS10360 (2084606) 2084606..2085361 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX22_RS10365 (2085373) 2085373..2085627 - 255 WP_000611512.1 phage holin -
OCX22_RS10370 (2085675) 2085675..2085782 + 108 WP_031762631.1 hypothetical protein -
- (2085704) 2085704..2085843 + 140 NuclAT_0 - Antitoxin
- (2085704) 2085704..2085843 + 140 NuclAT_0 - Antitoxin
- (2085704) 2085704..2085843 + 140 NuclAT_0 - Antitoxin
- (2085704) 2085704..2085843 + 140 NuclAT_0 - Antitoxin
OCX22_RS10375 (2085835) 2085835..2086011 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX22_RS10380 (2086120) 2086120..2086893 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
OCX22_RS10385 (2087266) 2087266..2087640 - 375 WP_000340977.1 hypothetical protein -
OCX22_RS10390 (2087696) 2087696..2087983 - 288 WP_001262621.1 hypothetical protein -
OCX22_RS10395 (2088029) 2088029..2088181 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2082076..2136568 54492


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39259 WP_011447039.1 NZ_AP024723:c2086011-2085835 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39259 NZ_AP024723:c2086011-2085835 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39259 NZ_AP024723:2085704-2085843 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References