Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1979779..1980086 Replicon chromosome
Accession NZ_CP017680
Organism Staphylococcus aureus strain CFSAN007851

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag AB454_RS10130 Protein ID WP_011447039.1
Coordinates 1979910..1980086 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1979779..1979918 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB454_RS10070 1975344..1975523 + 180 WP_000669791.1 hypothetical protein -
AB454_RS10080 1975834..1976094 + 261 WP_001791826.1 hypothetical protein -
AB454_RS10085 1976147..1976497 - 351 WP_000702263.1 complement inhibitor SCIN-A -
AB454_RS10090 1977009..1977344 - 336 Protein_1847 SH3 domain-containing protein -
AB454_RS10110 1977995..1978486 - 492 WP_000920038.1 staphylokinase -
AB454_RS10115 1978677..1979432 - 756 WP_000861038.1 CHAP domain-containing protein -
AB454_RS10120 1979444..1979698 - 255 WP_000611512.1 phage holin -
AB454_RS10125 1979750..1979857 + 108 WP_031762631.1 hypothetical protein -
- 1979779..1979918 + 140 NuclAT_0 - Antitoxin
- 1979779..1979918 + 140 NuclAT_0 - Antitoxin
- 1979779..1979918 + 140 NuclAT_0 - Antitoxin
- 1979779..1979918 + 140 NuclAT_0 - Antitoxin
AB454_RS10130 1979910..1980086 - 177 WP_011447039.1 putative holin-like toxin Toxin
AB454_RS10135 1980195..1980968 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
AB454_RS10140 1981341..1981715 - 375 WP_000340977.1 hypothetical protein -
AB454_RS10145 1981771..1982058 - 288 WP_001262621.1 hypothetical protein -
AB454_RS10150 1982104..1982256 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 1976147..2034672 58525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T68003 WP_011447039.1 NZ_CP017680:c1980086-1979910 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T68003 NZ_CP017680:c1980086-1979910 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT68003 NZ_CP017680:1979779-1979918 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References