Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 71746..72084 Replicon chromosome
Accession NZ_CP026073
Organism Staphylococcus aureus strain FDAARGOS_42

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RL00_RS00445 Protein ID WP_011447039.1
Coordinates 71746..71922 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 71910..72084 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL00_RS00425 69576..69728 + 153 WP_001000058.1 hypothetical protein -
RL00_RS00430 69774..70061 + 288 WP_001262624.1 hypothetical protein -
RL00_RS00435 70117..70491 + 375 WP_000340977.1 hypothetical protein -
RL00_RS00440 70864..71637 + 774 WP_000750412.1 staphylococcal enterotoxin type A -
RL00_RS00445 71746..71922 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 71910..72084 - 175 - - Antitoxin
RL00_RS00455 72134..72388 + 255 WP_000611512.1 phage holin -
RL00_RS00460 72400..73155 + 756 WP_000861038.1 CHAP domain-containing protein -
RL00_RS00465 73346..73837 + 492 WP_000920039.1 staphylokinase -
RL00_RS00485 74488..74823 + 336 Protein_91 SH3 domain-containing protein -
RL00_RS00490 75335..75685 + 351 WP_000702263.1 complement inhibitor SCIN-A -
RL00_RS00495 75738..75998 - 261 WP_001791826.1 hypothetical protein -
RL00_RS00505 76309..76488 - 180 WP_000669791.1 hypothetical protein -
RL00_RS00510 76810..77060 - 251 Protein_95 sphingomyelin phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / selk / selq / sea / sak / scn 20184..75685 55501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T93139 WP_011447039.1 NZ_CP026073:71746-71922 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T93139 NZ_CP026073:71746-71922 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 175 bp

>AT93139 NZ_CP026073:c72084-71910 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References