Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2090264..2090571 Replicon chromosome
Accession NZ_AP024742
Organism Staphylococcus aureus strain 59736

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX51_RS10390 Protein ID WP_011447039.1
Coordinates 2090395..2090571 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2090264..2090403 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX51_RS10345 (2085264) 2085264..2085461 + 198 WP_000239610.1 phospholipase -
OCX51_RS10350 (2085833) 2085833..2086012 + 180 WP_000669791.1 hypothetical protein -
OCX51_RS10355 (2086323) 2086323..2086583 + 261 WP_001791826.1 hypothetical protein -
OCX51_RS10360 (2086636) 2086636..2086986 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX51_RS10365 (2087498) 2087498..2087833 - 336 Protein_2004 SH3 domain-containing protein -
OCX51_RS10370 (2088484) 2088484..2088975 - 492 WP_000920038.1 staphylokinase -
OCX51_RS10375 (2089166) 2089166..2089921 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX51_RS10380 (2089933) 2089933..2090187 - 255 WP_000611512.1 phage holin -
OCX51_RS10385 (2090235) 2090235..2090342 + 108 WP_031762631.1 hypothetical protein -
- (2090264) 2090264..2090403 + 140 NuclAT_0 - Antitoxin
- (2090264) 2090264..2090403 + 140 NuclAT_0 - Antitoxin
- (2090264) 2090264..2090403 + 140 NuclAT_0 - Antitoxin
- (2090264) 2090264..2090403 + 140 NuclAT_0 - Antitoxin
OCX51_RS10390 (2090395) 2090395..2090571 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX51_RS10395 (2090680) 2090680..2091453 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
OCX51_RS10400 (2091826) 2091826..2092200 - 375 WP_000340977.1 hypothetical protein -
OCX51_RS10405 (2092256) 2092256..2092543 - 288 WP_001262621.1 hypothetical protein -
OCX51_RS10410 (2092589) 2092589..2092741 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2086636..2145150 58514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39410 WP_011447039.1 NZ_AP024742:c2090571-2090395 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39410 NZ_AP024742:c2090571-2090395 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39410 NZ_AP024742:2090264-2090403 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References