39370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2081181..2081488 Replicon chromosome
Accession NZ_AP024736
Organism Staphylococcus aureus strain 59709

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX48_RS10355 Protein ID WP_011447039.1
Coordinates 2081312..2081488 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2081181..2081320 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX48_RS10310 (2076181) 2076181..2076378 + 198 WP_000239610.1 phospholipase -
OCX48_RS10315 (2076750) 2076750..2076929 + 180 WP_000669791.1 hypothetical protein -
OCX48_RS10320 (2077240) 2077240..2077500 + 261 WP_001791826.1 hypothetical protein -
OCX48_RS10325 (2077553) 2077553..2077903 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX48_RS10330 (2078415) 2078415..2078750 - 336 Protein_1997 SH3 domain-containing protein -
OCX48_RS10335 (2079401) 2079401..2079892 - 492 WP_000920038.1 staphylokinase -
OCX48_RS10340 (2080083) 2080083..2080838 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX48_RS10345 (2080850) 2080850..2081104 - 255 WP_000611512.1 phage holin -
OCX48_RS10350 (2081152) 2081152..2081259 + 108 WP_031762631.1 hypothetical protein -
- (2081181) 2081181..2081320 + 140 NuclAT_0 - Antitoxin
- (2081181) 2081181..2081320 + 140 NuclAT_0 - Antitoxin
- (2081181) 2081181..2081320 + 140 NuclAT_0 - Antitoxin
- (2081181) 2081181..2081320 + 140 NuclAT_0 - Antitoxin
OCX48_RS10355 (2081312) 2081312..2081488 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX48_RS10360 (2081597) 2081597..2082370 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
OCX48_RS10365 (2082743) 2082743..2083117 - 375 WP_000340977.1 hypothetical protein -
OCX48_RS10370 (2083173) 2083173..2083460 - 288 WP_001262621.1 hypothetical protein -
OCX48_RS10375 (2083506) 2083506..2083658 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2077553..2133041 55488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39370 WP_011447039.1 NZ_AP024736:c2081488-2081312 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39370 NZ_AP024736:c2081488-2081312 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39370 NZ_AP024736:2081181-2081320 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References