Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2009243..2009550 Replicon chromosome
Accession NZ_CP070986
Organism Staphylococcus aureus strain WBG8287

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag JYH18_RS09720 Protein ID WP_011447039.1
Coordinates 2009374..2009550 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2009243..2009382 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYH18_RS09680 2004808..2004987 + 180 WP_000669791.1 hypothetical protein -
JYH18_RS09685 2005298..2005558 + 261 WP_001791826.1 hypothetical protein -
JYH18_RS09690 2005611..2005961 - 351 WP_000702263.1 complement inhibitor SCIN-A -
JYH18_RS09695 2006473..2006808 - 336 Protein_1872 SH3 domain-containing protein -
JYH18_RS09700 2007459..2007950 - 492 WP_000920038.1 staphylokinase -
JYH18_RS09705 2008141..2008896 - 756 WP_000861025.1 CHAP domain-containing protein -
JYH18_RS09710 2008908..2009162 - 255 WP_000611512.1 phage holin -
JYH18_RS09715 2009214..2009321 + 108 WP_031762631.1 hypothetical protein -
- 2009243..2009382 + 140 NuclAT_0 - Antitoxin
- 2009243..2009382 + 140 NuclAT_0 - Antitoxin
- 2009243..2009382 + 140 NuclAT_0 - Antitoxin
- 2009243..2009382 + 140 NuclAT_0 - Antitoxin
JYH18_RS09720 2009374..2009550 - 177 WP_011447039.1 putative holin-like toxin Toxin
JYH18_RS09725 2009659..2010432 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
JYH18_RS09730 2010805..2011179 - 375 WP_061653202.1 hypothetical protein -
JYH18_RS09735 2011235..2011522 - 288 WP_001262621.1 hypothetical protein -
JYH18_RS09740 2011568..2011720 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2005611..2064020 58409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T194930 WP_011447039.1 NZ_CP070986:c2009550-2009374 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T194930 NZ_CP094230:476930-477271 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 140 bp

>AT194930 NZ_CP070986:2009243-2009382 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References