Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1532300..1532638 Replicon chromosome
Accession NZ_CP026964
Organism Staphylococcus aureus strain FDAARGOS_2

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag RK61_RS07830 Protein ID WP_011447039.1
Coordinates 1532300..1532476 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1532464..1532638 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK61_RS07810 1530130..1530282 + 153 WP_001000058.1 hypothetical protein -
RK61_RS07815 1530328..1530615 + 288 WP_001262621.1 hypothetical protein -
RK61_RS07820 1530671..1531045 + 375 WP_000340977.1 hypothetical protein -
RK61_RS07825 1531418..1532191 + 774 WP_000750412.1 staphylococcal enterotoxin type A -
RK61_RS07830 1532300..1532476 + 177 WP_011447039.1 putative holin-like toxin Toxin
- 1532464..1532638 - 175 - - Antitoxin
RK61_RS07840 1532688..1532942 + 255 WP_000611512.1 phage holin -
RK61_RS07845 1532954..1533709 + 756 WP_000861025.1 CHAP domain-containing protein -
RK61_RS07850 1533900..1534391 + 492 WP_000920038.1 staphylokinase -
RK61_RS07870 1535042..1535377 + 336 Protein_1460 SH3 domain-containing protein -
RK61_RS07875 1535889..1536239 + 351 WP_000702263.1 complement inhibitor SCIN-A -
RK61_RS07880 1536292..1536552 - 261 WP_001791826.1 hypothetical protein -
RK61_RS07890 1536863..1537042 - 180 WP_000669791.1 hypothetical protein -
RK61_RS07895 1537364..1537614 - 251 Protein_1464 sphingomyelin phosphodiesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - groEL / hlb / selk / selq / sea / sak / scn 1480742..1536239 55497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T96886 WP_011447039.1 NZ_CP026964:1532300-1532476 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T96886 NZ_CP026964:1532300-1532476 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 175 bp

>AT96886 NZ_CP026964:c1532638-1532464 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References