Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2045113..2045420 Replicon chromosome
Accession NZ_CP019574
Organism Staphylococcus aureus strain USA400-0051

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SAU400_RS10565 Protein ID WP_011447039.1
Coordinates 2045244..2045420 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2045113..2045252 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAU400_RS10505 2040679..2040858 + 180 WP_000669791.1 hypothetical protein -
SAU400_RS10515 2041169..2041429 + 261 WP_001791826.1 hypothetical protein -
SAU400_RS10520 2041482..2041832 - 351 WP_000702263.1 complement inhibitor SCIN-A -
SAU400_RS10525 2042343..2042678 - 336 Protein_1933 SH3 domain-containing protein -
SAU400_RS10545 2043329..2043820 - 492 WP_000920039.1 staphylokinase -
SAU400_RS10550 2044011..2044766 - 756 WP_000861038.1 CHAP domain-containing protein -
SAU400_RS10555 2044778..2045032 - 255 WP_000611512.1 phage holin -
SAU400_RS10560 2045084..2045191 + 108 WP_031762631.1 hypothetical protein -
- 2045113..2045252 + 140 NuclAT_0 - Antitoxin
- 2045113..2045252 + 140 NuclAT_0 - Antitoxin
- 2045113..2045252 + 140 NuclAT_0 - Antitoxin
- 2045113..2045252 + 140 NuclAT_0 - Antitoxin
SAU400_RS10565 2045244..2045420 - 177 WP_011447039.1 putative holin-like toxin Toxin
SAU400_RS10570 2045528..2046301 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
SAU400_RS10575 2046674..2047048 - 375 WP_000340977.1 hypothetical protein -
SAU400_RS10580 2047104..2047391 - 288 WP_001262624.1 hypothetical protein -
SAU400_RS10585 2047437..2047589 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2041482..2096979 55497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T72691 WP_011447039.1 NZ_CP019574:c2045420-2045244 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T72691 NZ_CP019574:c2045420-2045244 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT72691 NZ_CP019574:2045113-2045252 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References