20609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2030286..2030593 Replicon chromosome
Accession NC_002953
Organism Staphylococcus aureus subsp. aureus MSSA476

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag SAS_RS14785 Protein ID WP_011447039.1
Coordinates 2030417..2030593 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2030286..2030425 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAS_RS10120 2025851..2026030 + 180 WP_000669791.1 hypothetical protein -
SAS_RS10130 2026341..2026601 + 261 WP_001791826.1 hypothetical protein -
SAS_RS10135 2026654..2027004 - 351 WP_000702263.1 complement inhibitor SCIN-A -
SAS_RS10140 2027516..2027851 - 336 Protein_1909 SH3 domain-containing protein -
SAS_RS10145 2028502..2028993 - 492 WP_000920038.1 staphylokinase -
SAS_RS10150 2029184..2029939 - 756 WP_000861025.1 CHAP domain-containing protein -
SAS_RS10155 2029951..2030205 - 255 WP_000611512.1 phage holin -
SAS_RS10160 2030257..2030364 + 108 WP_031762631.1 hypothetical protein -
- 2030286..2030425 + 140 NuclAT_0 - Antitoxin
- 2030286..2030425 + 140 NuclAT_0 - Antitoxin
- 2030286..2030425 + 140 NuclAT_0 - Antitoxin
- 2030286..2030425 + 140 NuclAT_0 - Antitoxin
SAS_RS14785 2030417..2030593 - 177 WP_011447039.1 putative holin-like toxin Toxin
SAS_RS10170 2030702..2031475 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
SAS_RS10175 2031848..2032222 - 375 WP_000340977.1 hypothetical protein -
SAS_RS10180 2032278..2032565 - 288 WP_001262621.1 hypothetical protein -
SAS_RS10185 2032611..2032763 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2026654..2082151 55497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T20609 WP_011447039.1 NC_002953:c2030593-2030417 [Staphylococcus aureus subsp. aureus MSSA476]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T20609 NC_002953:c2030593-2030417 [Staphylococcus aureus subsp. aureus MSSA476]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT20609 NC_002953:2030286-2030425 [Staphylococcus aureus subsp. aureus MSSA476]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References