Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2042573..2042880 Replicon chromosome
Accession NZ_AP024728
Organism Staphylococcus aureus strain 59553

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX18_RS10060 Protein ID WP_011447039.1
Coordinates 2042704..2042880 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2042573..2042712 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX18_RS10015 (2037574) 2037574..2037771 + 198 WP_000239610.1 phospholipase -
OCX18_RS10020 (2038143) 2038143..2038322 + 180 WP_000669791.1 hypothetical protein -
OCX18_RS10025 (2038633) 2038633..2038893 + 261 WP_001791826.1 hypothetical protein -
OCX18_RS10030 (2038946) 2038946..2039296 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX18_RS10035 (2039807) 2039807..2040142 - 336 Protein_1939 SH3 domain-containing protein -
OCX18_RS10040 (2040793) 2040793..2041284 - 492 WP_000920038.1 staphylokinase -
OCX18_RS10045 (2041475) 2041475..2042230 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX18_RS10050 (2042242) 2042242..2042496 - 255 WP_000611512.1 phage holin -
OCX18_RS10055 (2042544) 2042544..2042651 + 108 WP_031762631.1 hypothetical protein -
- (2042573) 2042573..2042712 + 140 NuclAT_0 - Antitoxin
- (2042573) 2042573..2042712 + 140 NuclAT_0 - Antitoxin
- (2042573) 2042573..2042712 + 140 NuclAT_0 - Antitoxin
- (2042573) 2042573..2042712 + 140 NuclAT_0 - Antitoxin
OCX18_RS10060 (2042704) 2042704..2042880 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX18_RS10065 (2042989) 2042989..2043762 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
OCX18_RS10070 (2044135) 2044135..2044509 - 375 WP_000340977.1 hypothetical protein -
OCX18_RS10075 (2044565) 2044565..2044852 - 288 WP_001262621.1 hypothetical protein -
OCX18_RS10080 (2044898) 2044898..2045050 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2038946..2094433 55487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39294 WP_011447039.1 NZ_AP024728:c2042880-2042704 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39294 NZ_AP024728:c2042880-2042704 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39294 NZ_AP024728:2042573-2042712 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References