Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1754588..1754895 Replicon chromosome
Accession NZ_CP062348
Organism Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag IF738_RS08875 Protein ID WP_011447039.1
Coordinates 1754719..1754895 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1754588..1754727 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF738_RS08835 (1750153) 1750153..1750332 + 180 WP_000669792.1 hypothetical protein -
IF738_RS08840 (1750643) 1750643..1750903 + 261 WP_001791826.1 hypothetical protein -
IF738_RS08845 (1750956) 1750956..1751306 - 351 WP_000702263.1 complement inhibitor SCIN-A -
IF738_RS08850 (1751818) 1751818..1752153 - 336 Protein_1707 SH3 domain-containing protein -
IF738_RS08855 (1752804) 1752804..1753295 - 492 WP_000920038.1 staphylokinase -
IF738_RS08860 (1753486) 1753486..1754241 - 756 WP_000861027.1 CHAP domain-containing protein -
IF738_RS08865 (1754253) 1754253..1754507 - 255 WP_000611512.1 phage holin -
IF738_RS08870 (1754559) 1754559..1754666 + 108 WP_031762631.1 hypothetical protein -
- (1754588) 1754588..1754727 + 140 NuclAT_0 - Antitoxin
- (1754588) 1754588..1754727 + 140 NuclAT_0 - Antitoxin
- (1754588) 1754588..1754727 + 140 NuclAT_0 - Antitoxin
- (1754588) 1754588..1754727 + 140 NuclAT_0 - Antitoxin
IF738_RS08875 (1754719) 1754719..1754895 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
IF738_RS08880 (1755004) 1755004..1755777 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
IF738_RS08885 (1756150) 1756150..1756524 - 375 WP_000340977.1 hypothetical protein -
IF738_RS08890 (1756580) 1756580..1756867 - 288 WP_001262621.1 hypothetical protein -
IF738_RS08895 (1756913) 1756913..1757065 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / sak / sea / selq / selk / hlb / groEL 1747145..1806457 59312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T174483 WP_011447039.1 NZ_CP062348:c1754895-1754719 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T174483 NZ_CP081010:c4231970-4231656 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 140 bp

>AT174483 NZ_CP062348:1754588-1754727 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References