Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2094870..2095177 Replicon chromosome
Accession NZ_AP018923
Organism Staphylococcus aureus strain JMUB3031

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag D5070_RS10910 Protein ID WP_011447039.1
Coordinates 2095001..2095177 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2094870..2095009 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5070_RS10850 2090439..2090618 + 180 WP_000669791.1 hypothetical protein -
D5070_RS10860 2090929..2091189 + 261 WP_001791826.1 hypothetical protein -
D5070_RS10865 2091242..2091592 - 351 WP_000702263.1 complement inhibitor SCIN-A -
D5070_RS10870 2092104..2092439 - 336 Protein_2002 SH3 domain-containing protein -
D5070_RS10890 2093090..2093581 - 492 WP_000920038.1 staphylokinase -
D5070_RS10895 2093772..2094527 - 756 WP_119305755.1 CHAP domain-containing protein -
D5070_RS10900 2094539..2094793 - 255 WP_000611512.1 phage holin -
D5070_RS10905 2094841..2094948 + 108 WP_031762631.1 hypothetical protein -
- 2094870..2095009 + 140 NuclAT_0 - Antitoxin
- 2094870..2095009 + 140 NuclAT_0 - Antitoxin
- 2094870..2095009 + 140 NuclAT_0 - Antitoxin
- 2094870..2095009 + 140 NuclAT_0 - Antitoxin
D5070_RS10910 2095001..2095177 - 177 WP_011447039.1 putative holin-like toxin Toxin
D5070_RS10915 2095286..2096059 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
D5070_RS10920 2096432..2096806 - 375 WP_000340977.1 hypothetical protein -
D5070_RS10925 2096862..2097149 - 288 WP_001262621.1 hypothetical protein -
D5070_RS10930 2097195..2097347 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / sak / sea / selq / selk / hlb / groEL 2087432..2146718 59286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T32445 WP_011447039.1 NZ_AP018923:c2095177-2095001 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T32445 NZ_AP018923:c2095177-2095001 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT32445 NZ_AP018923:2094870-2095009 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References