283502

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2163983..2164248 Replicon chromosome
Accession NZ_CP127019
Organism Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M

Toxin (Protein)


Gene name txpA Uniprot ID W8TS34
Locus tag QQO11_RS10885 Protein ID WP_000226108.1
Coordinates 2164114..2164248 (-) Length 45 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2163983..2164122 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO11_RS10845 (2159549) 2159549..2159728 + 180 WP_000669791.1 hypothetical protein -
QQO11_RS10850 (2160039) 2160039..2160299 + 261 WP_001791826.1 hypothetical protein -
QQO11_RS10855 (2160352) 2160352..2160702 - 351 WP_000702263.1 complement inhibitor SCIN-A -
QQO11_RS10860 (2161213) 2161213..2161548 - 336 Protein_2105 SH3 domain-containing protein -
QQO11_RS10865 (2162199) 2162199..2162690 - 492 WP_000920038.1 staphylokinase -
QQO11_RS10870 (2162881) 2162881..2163636 - 756 WP_000861038.1 CHAP domain-containing protein -
QQO11_RS10875 (2163648) 2163648..2163902 - 255 WP_000611512.1 phage holin -
QQO11_RS10880 (2163954) 2163954..2164061 + 108 WP_031762631.1 hypothetical protein -
- (2163983) 2163983..2164122 + 140 NuclAT_0 - Antitoxin
- (2163983) 2163983..2164122 + 140 NuclAT_0 - Antitoxin
- (2163983) 2163983..2164122 + 140 NuclAT_0 - Antitoxin
- (2163983) 2163983..2164122 + 140 NuclAT_0 - Antitoxin
QQO11_RS10885 (2164114) 2164114..2164248 - 135 WP_000226108.1 type I toxin-antitoxin system toxin PepG1 Toxin
QQO11_RS10890 (2164399) 2164399..2165172 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
QQO11_RS10895 (2165545) 2165545..2165919 - 375 WP_000340977.1 hypothetical protein -
QQO11_RS10900 (2165975) 2165975..2166262 - 288 WP_285236782.1 hypothetical protein -
QQO11_RS10905 (2166308) 2166308..2166460 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / hlb / groEL 2160352..2216881 56529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(16-44)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 5029.35 Da        Isoelectric Point: 11.7213

>T283502 WP_000226108.1 NZ_CP127019:c2164248-2164114 [Staphylococcus aureus]
MVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 135 bp

Antitoxin


Download         Length: 140 bp

>AT283502 NZ_CP127019:2163983-2164122 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8TS34

Antitoxin

Download structure file

References