39279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2068090..2068397 Replicon chromosome
Accession NZ_AP024726
Organism Staphylococcus aureus strain 59482

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX11_RS10305 Protein ID WP_011447039.1
Coordinates 2068221..2068397 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2068090..2068229 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX11_RS10260 (2063090) 2063090..2063287 + 198 WP_000239610.1 phospholipase -
OCX11_RS10265 (2063659) 2063659..2063838 + 180 WP_000669791.1 hypothetical protein -
OCX11_RS10270 (2064149) 2064149..2064409 + 261 WP_001791826.1 hypothetical protein -
OCX11_RS10275 (2064462) 2064462..2064812 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX11_RS10280 (2065324) 2065324..2065659 - 336 Protein_1987 SH3 domain-containing protein -
OCX11_RS10285 (2066310) 2066310..2066801 - 492 WP_000920038.1 staphylokinase -
OCX11_RS10290 (2066992) 2066992..2067747 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX11_RS10295 (2067759) 2067759..2068013 - 255 WP_000611512.1 phage holin -
OCX11_RS10300 (2068061) 2068061..2068168 + 108 WP_031762631.1 hypothetical protein -
- (2068090) 2068090..2068229 + 140 NuclAT_0 - Antitoxin
- (2068090) 2068090..2068229 + 140 NuclAT_0 - Antitoxin
- (2068090) 2068090..2068229 + 140 NuclAT_0 - Antitoxin
- (2068090) 2068090..2068229 + 140 NuclAT_0 - Antitoxin
OCX11_RS10305 (2068221) 2068221..2068397 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX11_RS10310 (2068506) 2068506..2069279 - 774 WP_261925355.1 staphylococcal enterotoxin type A -
OCX11_RS10315 (2069652) 2069652..2070026 - 375 WP_000340977.1 hypothetical protein -
OCX11_RS10320 (2070082) 2070082..2070369 - 288 WP_001262621.1 hypothetical protein -
OCX11_RS10325 (2070415) 2070415..2070567 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2064462..2122975 58513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39279 WP_011447039.1 NZ_AP024726:c2068397-2068221 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39279 NZ_AP024726:c2068397-2068221 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39279 NZ_AP024726:2068090-2068229 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References