Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-MW1433/-
Location 2033261..2033568 Replicon chromosome
Accession NZ_CP017115
Organism Staphylococcus aureus strain FORC_045

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag FORC45_RS10515 Protein ID WP_011447039.1
Coordinates 2033392..2033568 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 2033261..2033400 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC45_RS10455 2028826..2029005 + 180 WP_000669791.1 hypothetical protein -
FORC45_RS10465 2029316..2029576 + 261 WP_001791826.1 hypothetical protein -
FORC45_RS10470 2029629..2029979 - 351 WP_000702263.1 complement inhibitor SCIN-A -
FORC45_RS10475 2030491..2030826 - 336 Protein_1930 SH3 domain-containing protein -
FORC45_RS10495 2031477..2031968 - 492 WP_000920038.1 staphylokinase -
FORC45_RS10500 2032159..2032914 - 756 WP_000861025.1 CHAP domain-containing protein -
FORC45_RS10505 2032926..2033180 - 255 WP_000611512.1 phage holin -
FORC45_RS10510 2033232..2033339 + 108 WP_031762631.1 hypothetical protein -
- 2033261..2033400 + 140 NuclAT_0 - Antitoxin
- 2033261..2033400 + 140 NuclAT_0 - Antitoxin
- 2033261..2033400 + 140 NuclAT_0 - Antitoxin
- 2033261..2033400 + 140 NuclAT_0 - Antitoxin
FORC45_RS10515 2033392..2033568 - 177 WP_011447039.1 putative holin-like toxin Toxin
FORC45_RS10520 2033677..2034450 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
FORC45_RS10525 2034823..2035197 - 375 WP_000340977.1 hypothetical protein -
FORC45_RS10530 2035253..2035540 - 288 WP_001262621.1 hypothetical protein -
FORC45_RS10535 2035586..2035738 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - map / hlb / scn / sak / sea / selq / selk / hlb 2025819..2074179 48360


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T66039 WP_011447039.1 NZ_CP017115:c2033568-2033392 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T66039 NZ_CP017115:c2033568-2033392 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT66039 NZ_CP017115:2033261-2033400 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References