Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2038173..2038480 Replicon chromosome
Accession NZ_AP024732
Organism Staphylococcus aureus strain 59621

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OCX17_RS10070 Protein ID WP_011447039.1
Coordinates 2038304..2038480 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2038173..2038312 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCX17_RS10025 (2033173) 2033173..2033370 + 198 WP_000239610.1 phospholipase -
OCX17_RS10030 (2033742) 2033742..2033921 + 180 WP_000669791.1 hypothetical protein -
OCX17_RS10035 (2034232) 2034232..2034492 + 261 WP_001791826.1 hypothetical protein -
OCX17_RS10040 (2034545) 2034545..2034895 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OCX17_RS10045 (2035407) 2035407..2035742 - 336 Protein_1940 SH3 domain-containing protein -
OCX17_RS10050 (2036393) 2036393..2036884 - 492 WP_000920038.1 staphylokinase -
OCX17_RS10055 (2037075) 2037075..2037830 - 756 WP_000861038.1 CHAP domain-containing protein -
OCX17_RS10060 (2037842) 2037842..2038096 - 255 WP_000611512.1 phage holin -
OCX17_RS10065 (2038144) 2038144..2038251 + 108 WP_031762631.1 hypothetical protein -
- (2038173) 2038173..2038312 + 140 NuclAT_0 - Antitoxin
- (2038173) 2038173..2038312 + 140 NuclAT_0 - Antitoxin
- (2038173) 2038173..2038312 + 140 NuclAT_0 - Antitoxin
- (2038173) 2038173..2038312 + 140 NuclAT_0 - Antitoxin
OCX17_RS10070 (2038304) 2038304..2038480 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OCX17_RS10075 (2038589) 2038589..2039362 - 774 WP_000750412.1 staphylococcal enterotoxin type A -
OCX17_RS10080 (2039735) 2039735..2040109 - 375 WP_000340977.1 hypothetical protein -
OCX17_RS10085 (2040165) 2040165..2040452 - 288 WP_001262621.1 hypothetical protein -
OCX17_RS10090 (2040498) 2040498..2040650 - 153 WP_001000058.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - scn / sak / sea / selq / selk / hlb / groEL 2034545..2093022 58477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T39330 WP_011447039.1 NZ_AP024732:c2038480-2038304 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

>T39330 NZ_AP024732:c2038480-2038304 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 140 bp

>AT39330 NZ_AP024732:2038173-2038312 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References