SecReT6, T6SS database

Klebsiella pneumoniae

Experimental investigation has been performed.

Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS00344	i2	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	chromosome (NC_012731)	2298791..2328477	anti-bacterial; anti-eukaryotic
T6SS00345	Unknown	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	chromosome (NC_012731)	3190436..3214872	anti-bacterial; anti-eukaryotic
T6SS01214	Unknown	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	950009..972445	anti-bacterial; anti-eukaryotic
T6SS01215	i2	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2564540..2589406	anti-bacterial; anti-eukaryotic
T6SS01216	Unknown	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3477664..3505840	anti-bacterial; anti-eukaryotic
T6SS01273	Unknown	Klebsiella pneumoniae subsp. pneumoniae ATCC 43816	chromosome (NZ_CP064352)	850912..879397	anti-bacterial
T6SS01274	i2	Klebsiella pneumoniae subsp. pneumoniae ATCC 43816	chromosome (NZ_CP064352)	1759057..1784245	-
T6SS00548	i2	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2326237..2353260	anti-bacterial

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0203	KP1_3314 (hns)	T6SS00344	protein	Global regulator	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	chromosome (NC_012731)	3140175..3140582 (+)	238895262	KP1_2392 (TssB) promotor (↑); KP1_2392 (hcp) (↑)
REG0338	BN49_RS12735 (phoQ)	T6SS01214	protein	TCS-RR	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2324171..2325637 (-)	490249900	TssB transcription (↓)
REG0339	BN49_RS12735 (phoP)	T6SS01214	protein	TCS-HK	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2325637..2326308 (-)	490252783	BN49_2224 (phoQ) (↓)
REG0340	BN49_RS29275 (mgrB)	T6SS01214	protein	TCS regulatory pathway	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3583038..3583181 (-)	489000713	phoPQ (↑)
REG0341	BN49_RS21260 (rcsB)	T6SS01214	protein	TCS-RR	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	4066268..4066918 (+)	489002368	phoPQ (↑)
REG0342	BN49_RS18480 (h-ns)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3427636..3428043 (+)	488999426	TssB transcription (↑)
REG0343	BN49_RS10300 (fur)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	1826878..1827330 (-)	514077307	TssB transcription (↓)
REG0344	BN49_RS26620 (hfq)	T6SS01214	protein	QS regulatory pathway	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	5173711..5174019 (-)	488974767	TssB transcription (↓)
REG0345	BN49_RS03755 (rpoN)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	533564..534997 (-)	489007850	TssB transcription (↓)
REG0346	BN49_RS06445 (rpoS)	T6SS01214	protein	Global regulator	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	1060243..1061235 (+)	489004494	TssB transcription (↓)

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01826	BN49_RS18800 (VgrG4)	Tse	IMU00349	T6SS01216	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3498991..3501690 (-)	802146982
EFF18621	KPHS_23105 (Tle1^KP)	Tle	IMU17297	T6SS00548	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2341000..2343418 (+)	-

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector
IMU00349	BN49_RS18785 (Sel1E)	T6SS01216	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	3496153..3497427 (-)	802146974	EFF01826
IMU17297	KPHS_23060 (Tli1^KP)	T6SS00548	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2338687..2339217 (+)	YP_005226606.1	EFF18621
IMU17298	KPHS_23070 (Tli2^KP)	T6SS00548	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2339286..2339816 (+)	YP_005226607.1	EFF18621
IMU17299	KPHS_23080 (Tli3^KP)	T6SS00548	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2339884..2340414 (+)	YP_005226608.1	EFF18621
IMU17300	KPHS_23090 (Tli4^KP)	T6SS00548	Klebsiella pneumoniae subsp. pneumoniae HS11286	chromosome (NC_016845)	2340482..2341012 (+)	YP_005226609.1	EFF18621

Experimental investigation has been performed.

Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function
RSF000056	KPST380_RS07600 (wza)	Klebsiella pneumoniae subsp. pneumoniae BJ1-GA	chromosome (NZ_HG518479)	3683821..3684957 (-)	WP_004180522.1	protective	capsule protection
RSF000057	KP1_RS17340 (wza)	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	chromosome (NC_012731)	3540983..3542116 (-)	WP_014907221.1	protective	capsule protection
RSF000059	LGM18_RS08295 (wza)	Klebsiella pneumoniae strain SB617	chromosome (NZ_CP084825)	1719795..1720931 (+)	WP_136085646.1	protective	capsule protection
RSF000060	KPNJ1_RS09040 (wza)	Klebsiella pneumoniae 30660/NJST258_1	chromosome (NZ_CP006923)	1798389..1799522 (+)	WP_004151152.1	protective	capsule protection

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector