Experimental investigation has been performed.
Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS01112	i1	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	116945..140733	-

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0036	VC1920/VCA1552_01695 (LonA)	T6SS01112	protein	Unknown	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1845472..1847832 (-)	446970355	Unknown (↑)
REG0290	VCA1552_01380 (VdcA/ycdT)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1482426..1483715 (+)	446892247	the levels of c-di-GMP (↑)
REG0291	VCA1552_02536 (CdpA/YfgF)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2739669..2742158 (-)	446417730	the levels of c-di-GMP (↓)
REG0293	VCA1552_00351 (HapR)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	340447..341058 (-)	446262243	Unknown; Hcp expression and secretion
REG0294	VCA1552_RS04890 (ihfA)	T6SS01112	protein	Transcription regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1028170..1028466 (+)	447152004	Hcp secretion (↓)
REG0295	VCA1552_RS08565 (ihfB)	T6SS01112	protein	Transcription regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1839353..1839631 (-)	446089486	Hcp secretion (↓)
REG0296	VCA1552_RS03895 (LuxO)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	818142..819509 (+)	487814784	Hcp expression and secretion (↑)
REG0298	VCA1552_RS01665 (LuxS)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	319588..320106 (+)	447052971	Hcp expression and secretion (↓)
REG0299	VCA1552_RS00505 (hfq)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	92673..92936 (+)	446974616	VCA1552_00351 (HapR) (↑)
REG0300	VCA1552_RS11610 (RpoN)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2488023..2489486 (+)	446727517	Hcp expression and secretion (↓)
REG0301	VCA1552_RS12025 (crp)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2558371..2559003 (+)	446164894	Hcp expression and secretion (↓)
REG0302	VCA1552_RS12925 (cya)	T6SS01112	protein	QS regulatory pathway; cAMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2747346..2749877 (-)	447072406	VCA1552_RS12025 (crp) (↓)
REG0303	VCA1552_00154 (QstR)	T6SS01112	protein	c-di-GMP regulatory pathway; QS regulatory pathway; Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	149920..150564 (-)	447111060	TssB/TfoY transcripts (↓); VC0396/VCA1552_00154 (QstR) (↓); T6SS transcripts (↓)
REG0304	VCA1552_00900 (TfoX)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	952868..953476 (+)	487807468	VC0396/VCA1552_00154 (QstR) (↓)
REG0306	VCA1552_01510 (TfoY)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1636980..1637567 (+)	446282733	Unknown (↓)
REG0307	VCA1552_RS06160 (lonA)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1315238..1316887 (+)	446116573	VCA1552_01510 (TfoY) (↑)
REG0308	VCA1552_RS10420 (cdgL)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2215844..2217361 (-)	446975354	the levels of c-di-GMP (↓)
REG0309	VCA1552_RS04310 (cdgK)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	901594..903063 (+)	487807420	the levels of c-di-GMP (↓)
REG0310	VCA1552_RS04130 (cdgH)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	861187..863208 (+)	446848493	the levels of c-di-GMP (↓)
REG0311	VCA1552_RS02130 (rocS)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	425233..427287 (-)	447034155	the levels of c-di-GMP (↑)
REG0312	VCA1552_RS12850 (cdgJ)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	2733319..2734545 (-)	446210986	the levels of c-di-GMP (↑)
REG0292	VCA1552_02898 (VasH)	T6SS01112	protein	Global regulator	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	128889..130481 (+)	446006938	VCA1552_00900 (TfoX) (↓)
REG0297	VCA1552_RS17020 (cqsa)	T6SS01112	protein	QS regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	455238..456407 (-)	446962656	Hcp expression and secretion (↓)
REG0313	VCA1552_RS17835 (cdgD)	T6SS01112	protein	c-di-GMP regulatory pathway	Vibrio cholerae strain A1552	chromosome (NZ_CP024868)	633312..635195 (+)	446210820	the levels of c-di-GMP (↓)

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01850	VCA1552_RS05805 (hcp)	-	-	T6SS01112	Vibrio cholerae strain A1552	chromosome (NZ_CP024867)	1238150..1238668 (+)	447065691

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector

Experimental investigation has been performed.
Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function

Experimental investigation has been performed.
Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector