Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1704836..1705056 Replicon chromosome
Accession NC_013316
Organism Clostridium difficile R20291

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDR20291_RS07935 Protein ID WP_003429855.1
Coordinates 1704836..1704997 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1704917..1705056 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDR20291_RS07905 (CDR20291_1440) 1700693..1701130 + 438 WP_009888839.1 hypothetical protein -
CDR20291_RS07910 1701123..1701299 + 177 WP_009888840.1 hypothetical protein -
CDR20291_RS07915 (CDR20291_1441) 1701300..1702610 + 1311 WP_009893136.1 phage tail sheath family protein -
CDR20291_RS07920 (CDR20291_1442) 1702627..1703097 + 471 WP_009888842.1 phage tail tube protein -
CDR20291_RS07925 (CDR20291_1443) 1703156..1703983 + 828 WP_009888843.1 hypothetical protein -
CDR20291_RS07930 (CDR20291_1444) 1704055..1704495 + 441 WP_003429853.1 phage portal protein -
CDR20291_RS07935 (CDR20291_1445) 1704836..1704997 + 162 WP_003429855.1 hypothetical protein Toxin
- 1704917..1705056 - 140 - - Antitoxin
CDR20291_RS07940 1706334..1706522 + 189 WP_003429858.1 hypothetical protein -
CDR20291_RS07945 (CDR20291_1446) 1706641..1707507 + 867 WP_009888845.1 hypothetical protein -
CDR20291_RS07950 (CDR20291_1447) 1708372..1708899 + 528 WP_009888847.1 DUF4352 domain-containing protein -
CDR20291_RS07955 (CDR20291_1448) 1709037..1709804 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1671047..1738184 67137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T24266 WP_003429855.1 NC_013316:1704836-1704997 [Clostridioides difficile R20291]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T24266 NC_013316:1704836-1704997 [Clostridioides difficile R20291]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT24266 NC_013316:c1705056-1704917 [Clostridioides difficile R20291]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References