Detailed information of TA system TA105643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1718401..1718621
• Replicon: chromosome
• Accession: NZ_CP029423
• Organism: Clostridioides difficile R20291

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDIF27147_RS08075
• Protein ID: WP_003429855.1
• Coordinates: 1718401..1718562 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1718482..1718621 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDIF27147_RS08045	1714258..1714695	+	438	WP_009888839.1	hypothetical protein	-
CDIF27147_RS08050	1714688..1714864	+	177	WP_009888840.1	hypothetical protein	-
CDIF27147_RS08055	1714865..1716175	+	1311	WP_009893136.1	phage tail sheath family protein	-
CDIF27147_RS08060	1716192..1716662	+	471	WP_009888842.1	phage tail tube protein	-
CDIF27147_RS08065	1716721..1717548	+	828	WP_009888843.1	hypothetical protein	-
CDIF27147_RS08070	1717620..1718060	+	441	WP_003429853.1	phage portal protein	-
CDIF27147_RS08075	1718401..1718562	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1718482..1718621	-	140	-	-	Antitoxin
CDIF27147_RS08080	1719899..1720087	+	189	WP_003429858.1	hypothetical protein	-
CDIF27147_RS08085	1720206..1721072	+	867	WP_009888845.1	hypothetical protein	-
CDIF27147_RS08090	1721937..1722464	+	528	WP_009888847.1	DUF4352 domain-containing protein	-
CDIF27147_RS08095	1722602..1723369	+	768	WP_009888848.1	DUF4428 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_013316 Clostridium difficile R20291 Prophage TA024266 1671047..1738184 0	inside	Prophage	-	-	1684612..1751049	66437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T105643 WP_003429855.1 NZ_CP029423:1718401-1718562 [Clostridioides difficile R20291]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T105643 NZ_CP029423:1718401-1718562 [Clostridioides difficile R20291]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin

Nucleotide

• Length: 140 bp

>AT105643 NZ_CP029423:c1718621-1718482 [Clostridioides difficile R20291]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin