Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718401..1718621 Replicon chromosome
Accession NZ_CP029423
Organism Clostridioides difficile R20291

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDIF27147_RS08075 Protein ID WP_003429855.1
Coordinates 1718401..1718562 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718482..1718621 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF27147_RS08045 1714258..1714695 + 438 WP_009888839.1 hypothetical protein -
CDIF27147_RS08050 1714688..1714864 + 177 WP_009888840.1 hypothetical protein -
CDIF27147_RS08055 1714865..1716175 + 1311 WP_009893136.1 phage tail sheath family protein -
CDIF27147_RS08060 1716192..1716662 + 471 WP_009888842.1 phage tail tube protein -
CDIF27147_RS08065 1716721..1717548 + 828 WP_009888843.1 hypothetical protein -
CDIF27147_RS08070 1717620..1718060 + 441 WP_003429853.1 phage portal protein -
CDIF27147_RS08075 1718401..1718562 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718482..1718621 - 140 - - Antitoxin
CDIF27147_RS08080 1719899..1720087 + 189 WP_003429858.1 hypothetical protein -
CDIF27147_RS08085 1720206..1721072 + 867 WP_009888845.1 hypothetical protein -
CDIF27147_RS08090 1721937..1722464 + 528 WP_009888847.1 DUF4352 domain-containing protein -
CDIF27147_RS08095 1722602..1723369 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1684612..1751049 66437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T105643 WP_003429855.1 NZ_CP029423:1718401-1718562 [Clostridioides difficile R20291]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T105643 NZ_CP029423:1718401-1718562 [Clostridioides difficile R20291]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT105643 NZ_CP029423:c1718621-1718482 [Clostridioides difficile R20291]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References