Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1708973..1709193 Replicon chromosome
Accession NC_013315
Organism Clostridium difficile CD196

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CD196_RS19720 Protein ID WP_003429855.1
Coordinates 1708973..1709134 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1709054..1709193 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CD196_RS08065 1704830..1705267 + 438 WP_009888839.1 hypothetical protein -
CD196_RS19715 1705260..1705436 + 177 WP_009888840.1 hypothetical protein -
CD196_RS08075 1705437..1706747 + 1311 WP_009893136.1 phage tail sheath family protein -
CD196_RS08080 1706764..1707234 + 471 WP_009888842.1 phage tail tube protein -
CD196_RS08085 1707293..1708120 + 828 WP_009888843.1 hypothetical protein -
CD196_RS08090 1708192..1708632 + 441 WP_003429853.1 phage portal protein -
CD196_RS19720 1708973..1709134 + 162 WP_003429855.1 hypothetical protein Toxin
- 1709054..1709193 - 140 NuclAT_1 - Antitoxin
- 1709054..1709193 - 140 NuclAT_2 - Antitoxin
- 1709538..1709586 - 49 NuclAT_4 - -
- 1709538..1709586 - 49 NuclAT_5 - -
CD196_RS08100 1710471..1710659 + 189 WP_003429858.1 hypothetical protein -
CD196_RS08105 1710778..1711644 + 867 WP_009888845.1 hypothetical protein -
CD196_RS08115 1712509..1713036 + 528 WP_009888847.1 DUF4352 domain-containing protein -
CD196_RS08120 1713174..1713941 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1673422..1742321 68899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T24262 WP_003429855.1 NC_013315:1708973-1709134 [Clostridioides difficile CD196]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T24262 NC_013315:1708973-1709134 [Clostridioides difficile CD196]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT24262 NC_013315:c1709193-1709054 [Clostridioides difficile CD196]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References