Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1716988..1717208 Replicon chromosome
Accession NC_017179
Organism Clostridium difficile BI1

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CDBI1_RS08020 Protein ID WP_003429855.1
Coordinates 1716988..1717149 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1717069..1717208 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDBI1_RS07990 1712845..1713282 + 438 WP_009888839.1 hypothetical protein -
CDBI1_RS07995 1713275..1713451 + 177 WP_009888840.1 hypothetical protein -
CDBI1_RS08000 1713452..1714762 + 1311 WP_009893136.1 phage tail sheath family protein -
CDBI1_RS08005 1714779..1715249 + 471 WP_009888842.1 phage tail tube protein -
CDBI1_RS08010 1715308..1716135 + 828 WP_009888843.1 hypothetical protein -
CDBI1_RS08015 1716207..1716647 + 441 WP_003429853.1 phage portal protein -
CDBI1_RS08020 1716988..1717149 + 162 WP_003429855.1 hypothetical protein Toxin
- 1717069..1717208 - 140 NuclAT_1 - Antitoxin
- 1717069..1717208 - 140 NuclAT_2 - Antitoxin
- 1717553..1717601 - 49 NuclAT_4 - -
- 1717553..1717601 - 49 NuclAT_5 - -
CDBI1_RS08025 1718486..1718674 + 189 WP_003429858.1 hypothetical protein -
CDBI1_RS08030 1718793..1719659 + 867 WP_009888845.1 hypothetical protein -
CDBI1_RS08035 1720524..1721051 + 528 WP_009888847.1 DUF4352 domain-containing protein -
CDBI1_RS08040 1721189..1721956 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1683199..1749635 66436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T26341 WP_003429855.1 NC_017179:1716988-1717149 [Clostridioides difficile BI1]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T26341 NC_017179:1716988-1717149 [Clostridioides difficile BI1]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT26341 NC_017179:c1717208-1717069 [Clostridioides difficile BI1]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References