Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1607333..1607553 Replicon chromosome
Accession NZ_CP025044
Organism Clostridioides difficile strain R0104a

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag CWR57_RS07660 Protein ID WP_003429855.1
Coordinates 1607333..1607494 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1607414..1607553 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR57_RS07625 1603190..1603627 + 438 WP_009888839.1 hypothetical protein -
CWR57_RS07630 1603620..1603796 + 177 WP_009888840.1 hypothetical protein -
CWR57_RS07635 1603797..1605107 + 1311 WP_009893136.1 phage tail sheath family protein -
CWR57_RS07640 1605124..1605594 + 471 WP_009888842.1 phage tail tube protein -
CWR57_RS07645 1605653..1606480 + 828 WP_009888843.1 hypothetical protein -
CWR57_RS07650 1606552..1606992 + 441 WP_003429853.1 phage portal protein -
CWR57_RS07660 1607333..1607494 + 162 WP_003429855.1 hypothetical protein Toxin
- 1607414..1607553 - 140 NuclAT_1 - Antitoxin
- 1607414..1607553 - 140 NuclAT_2 - Antitoxin
- 1607898..1607946 - 49 NuclAT_4 - -
- 1607898..1607946 - 49 NuclAT_5 - -
CWR57_RS07665 1608831..1609019 + 189 WP_003429858.1 hypothetical protein -
CWR57_RS07670 1609138..1610004 + 867 WP_009888845.1 hypothetical protein -
CWR57_RS07680 1610869..1611396 + 528 WP_009888847.1 DUF4352 domain-containing protein -
CWR57_RS07685 1611534..1612301 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1576962..1639981 63019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T89589 WP_003429855.1 NZ_CP025044:1607333-1607494 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T89589 NZ_CP025044:1607333-1607494 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT89589 NZ_CP025044:c1607553-1607414 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References