Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718533..1718753 Replicon chromosome
Accession NZ_CP026595
Organism Clostridioides difficile strain 12-00011

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag C3350_RS08350 Protein ID WP_003429855.1
Coordinates 1718533..1718694 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718614..1718753 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3350_RS08315 1714390..1714827 + 438 WP_009888839.1 hypothetical protein -
C3350_RS08320 1714820..1714996 + 177 WP_009888840.1 hypothetical protein -
C3350_RS08325 1714997..1716307 + 1311 WP_009893136.1 phage tail sheath family protein -
C3350_RS08330 1716324..1716794 + 471 WP_009888842.1 phage tail tube protein -
C3350_RS08335 1716853..1717680 + 828 WP_009888843.1 hypothetical protein -
C3350_RS08340 1717752..1718192 + 441 WP_003429853.1 phage portal protein -
C3350_RS08350 1718533..1718694 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718614..1718753 - 140 NuclAT_1 - Antitoxin
- 1718614..1718753 - 140 NuclAT_2 - Antitoxin
- 1719098..1719146 - 49 NuclAT_4 - -
- 1719098..1719146 - 49 NuclAT_5 - -
C3350_RS08355 1720031..1720219 + 189 WP_003429858.1 hypothetical protein -
C3350_RS08360 1720338..1721204 + 867 WP_009888845.1 hypothetical protein -
C3350_RS08370 1722069..1722596 + 528 WP_009888847.1 DUF4352 domain-containing protein -
C3350_RS08375 1722734..1723501 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1684744..1751181 66437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T95223 WP_003429855.1 NZ_CP026595:1718533-1718694 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T95223 NZ_CP026595:1718533-1718694 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT95223 NZ_CP026595:c1718753-1718614 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References