Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718028..1718248 Replicon chromosome
Accession NZ_CP026592
Organism Clostridioides difficile strain CD-10-00484

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag C3W74_RS08335 Protein ID WP_003429855.1
Coordinates 1718028..1718189 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718109..1718248 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3W74_RS08300 1713885..1714322 + 438 WP_009888839.1 hypothetical protein -
C3W74_RS08305 1714315..1714491 + 177 WP_009888840.1 hypothetical protein -
C3W74_RS08310 1714492..1715802 + 1311 WP_009893136.1 phage tail sheath family protein -
C3W74_RS08315 1715819..1716289 + 471 WP_009888842.1 phage tail tube protein -
C3W74_RS08320 1716348..1717175 + 828 WP_009888843.1 hypothetical protein -
C3W74_RS08325 1717247..1717687 + 441 WP_003429853.1 phage portal protein -
C3W74_RS08335 1718028..1718189 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718109..1718248 - 140 NuclAT_1 - Antitoxin
- 1718109..1718248 - 140 NuclAT_2 - Antitoxin
- 1718593..1718641 - 49 NuclAT_4 - -
- 1718593..1718641 - 49 NuclAT_5 - -
C3W74_RS08340 1719526..1719714 + 189 WP_003429858.1 hypothetical protein -
C3W74_RS08345 1719833..1720699 + 867 WP_009888845.1 hypothetical protein -
C3W74_RS08355 1721564..1722091 + 528 WP_009888847.1 DUF4352 domain-containing protein -
C3W74_RS08360 1722229..1722996 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1684239..1750676 66437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T95211 WP_003429855.1 NZ_CP026592:1718028-1718189 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

>T95211 NZ_CP026592:1718028-1718189 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCACAAATTTAAAT
AA

Antitoxin


Download         Length: 140 bp

>AT95211 NZ_CP026592:c1718248-1718109 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References